Research progress on HIV-associated sensory neuropathy

doi:10.19871/j.cnki.xfcrbzz.2021.04.022

Abstract

Abstract: Sensory neuropathyis a common complication in people living with human immunodeficiency virus. Currently, a great number of patients cannot get effective treatment due to the clinicians have insufficient understanding of the clinical manifestation and mechanism of HIV-associated sensory neuropathy (HIV-SN)and lack of treatment methods. This paper reviews the progress of the risk factors, mechanisms and treatment of HIV-SNin order to improve the diagnosis and treatment of HIV-SN.

Key words: Acquired immune deficiency syndrome, Sensory neuropathy, Wnt signaling pathway, Envelope glycoprotein

Chen Yao, Han Yakun, Wu Qiang, He Renliang. Research progress on HIV-associated sensory neuropathy[J]. Electronic Journal of Emerging Infectious Diseases, 2021, 6(4): 361-367.

References

[1] GALLO RC.HIV/AIDS Research for the Future[J]. Cell Host Microbe, 2020,27(4):499-501.
[2] CHRISTENSEN DE, GANSER-PORNILLOS BK, JOHNSON JS, et al.Reconstitution and visualization of HIV-1 capsid-dependent replication and integration in vitro[J]. Science, 2020,370(6513).
[3] 唐欷柯, 彭智鹏, 梁联哨, 等. 艾滋病合并神经梅毒感染的最新研究进展[J/CD]. 新发传染病电子杂志, 2020,5(3):203-206.
[4] ORGANIZATION WH. Estimated number of people (all ages) living with HIV[EB/OL]. (2021-07-12)[2021-08-09]. https://www.who.int/data/gho/data/indicators/indicator-details/GHO/estimated-number-of-people-(all-ages)-living-with-hiv.
[5] GAFF J, OCTAVIANA F, PILLAY P, et al.TNF-Block Genotypes Influence Susceptibility to HIV-Associated Sensory Neuropathy in Indonesians and South Africans[J]. Int J Mol Sci, 2020,21(2).
[6] GAFF J, PILLAY P, CHERRY C, et al.The role of CAMKK2 polymorphisms in HIV-associated sensory neuropathy in South Africans[J]. J Neurol Sci, 2020,416:116987.
[7] FINNERUP NB, KUNER R, JENSEN TS.Neuropathic Pain: From Mechanisms to Treatment[J]. Physiol Rev, 2021,101(1):259-301.
[8] INOUE K, TSUDA M.Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential[J]. Nat Rev Neurosci, 2018,19(3):138-152.
[9] BANNISTER K, SACHAU J, Baron R, et al.Neuropathic Pain: Mechanism-Based Therapeutics[J]. Annu Rev Pharmacol Toxicol, 2020,60:257-274.
[10] ADEM KS, JANAKIRAMAN B, GEBREMESKEL B F, et al.Epidemiology and factors associated with peripheral neuropathy among HIV infected patients in Gondar, Ethiopia: A cross-sectional study[J]. PLoS One, 2019,14(1):e211354.
[11] ONOFRJ M, CICCOCIOPPO F, VARANESE S, et al.Acetyl-L-carnitine: from a biological curiosity to a drug for the peripheral nervous system and beyond[J]. Expert Rev Neurother, 2013,13(8):925-936.
[12] HUANG J, BLOE CB, ZHOU X, et al.The Role of the Spinal Wnt Signaling Pathway in HIV-Related Neuropathic Pain[J]. Cell Mol Neurobiol, 2020,40(7):1075-1085.
[13] CARLSON HB, ANTHONY EM, RUSSELL WJ, et al.Prophylaxis of isoniazid neuropathy with pyridoxine[J]. N Engl J Med, 1956,255(3):119-122.
[14] OCTAVIANA F, SAFRI AY, SETIAWAN DD, et al.Neuropathic pain in HIV patients receiving ART without stavudine in an Indonesia Referral Hospital[J]. J Neurol Sci, 2019,397:146-149.
[15] SCOTT W, GARCIA CM DS, KEMP H, et al.A qualitative study of the experience and impact of neuropathic pain in people living with HIV[J]. Pain, 2020,161(5):970-978.
[16] DE SOUZA A, CAUMO W, CALVETTI P U, et al.Comparison of pain burden and psychological factors in Brazilian women living with HIV and chronic neuropathic or nociceptive pain: An exploratory study[J]. PLoS One, 2018,13(5):e196718.
[17] WADLEY AL, CHERRY CL, PRICE P, et al.HIV neuropathy risk factors and symptom characterization in stavudine-exposed South Africans[J]. J Pain Symptom Manage, 2011,41(4):700-706.
[18] ELLIS RJ, DIAZ M, SACKTOR N, et al.Predictors of worsening neuropathy and neuropathic pain after 12 years in people with HIV[J]. Ann Clin Transl Neurol, 2020,7(7):1166-1173.
[19] ROUSTIT M, LOADER J, DEUSENBERY C, et al.Endothelial Dysfunction as a Link Between Cardiovascular Risk Factors and Peripheral Neuropathy in Diabetes[J]. J Clin Endocrinol Metab, 2016,101(9):3401-3408.
[20] ZUBIETA JK, HEITZEG MM, SMITH YR, et al.COMT val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor[J]. Science, 2003,299(5610):1240-1243.
[21] XU J, UMLAUF A, LETENDRE S, et al.Catechol-O-methyltransferase polymorphism Val158Met is associated with distal neuropathic pain in HIV-associated sensory neuropathy[J]. AIDS, 2019,33(10):1575-1582.
[22] CENTNER CM, CARRARA H, HARRISON TB, et al.Sensory polyneuropathy in human immunodeficiency virus-infected patients receiving tuberculosis treatment[J]. Int J Tuberc Lung Dis, 2014,18(1):27-33.
[23] DUDLEY M T, BORKUM M, BASERA W, et al.Peripheral neuropathy in HIV patients on antiretroviral therapy: Does it impact function?[J]. J Neurol Sci, 2019,406:116451.
[24] GANOR Y, REAL F, SENNEPIN A, et al.HIV-1 reservoirs in urethral macrophages of patients under suppressive antiretroviral therapy[J]. Nat Microbiol, 2019,4(4):633-644.
[25] CHAI Q, JOVASEVIC V, MALIKOV V, et al.HIV-1 counteracts an innate restriction by amyloid precursor protein resulting in neurodegeneration[J]. Nat Commun, 2017,8(1):1522.
[26] COOK AD, CHRISTENSEN AD, TEWARI D, et al.Immune Cytokines and Their Receptors in Inflammatory Pain[J]. Trends Immunol, 2018,39(3):240-255.
[27] MWESIGA EK, KADDUMUKASA M, MUGENYI L, et al.Classification and description of chronic pain among HIV positive patients in Uganda[J]. Afr Health Sci, 2019,19(2):1978-1987.
[28] LI Y, GUO YC, ZHANG XL, et al.CD4-binding obstacles in conformational transitions and allosteric communications of HIV gp120[J]. Biochim Biophys Acta Biomembr, 2020,1862(6):183217.
[29] CAPON DJ, WARD RH.The CD4-gp120 interaction and AIDS pathogenesis[J]. Annu Rev Immunol, 1991,9:649-678.
[30] 中华医学会感染病学分会艾滋病丙型肝炎学组, 中国疾病预防控制中心. 中国艾滋病诊疗指南(2018版)[J/CD]. 新发传染病电子杂志, 2019,4(2):65-84.
[31] YUAN S B, SHI Y, CHEN J, et al.Gp120 in the pathogenesis of human immunodeficiency virus-associated pain[J]. Ann Neurol, 2014,75(6):837-850.
[32] WANG Y, LIAO J, TANG SJ, et al.HIV-1 gp120 Upregulates Brain-Derived Neurotrophic Factor (BDNF) Expression in BV2 Cells via the Wnt/beta-Catenin Signaling Pathway[J]. J Mol Neurosci, 2017,62(2):199-208.
[33] YUAN SB, JI G, LI B, et al.A Wnt5a signaling pathway in the pathogenesis of HIV-1 gp120-induced pain[J]. Pain, 2015,156(7):1311-1319.
[34] GEMIGNANI A, PAUDICE P, PITTALUGA A, et al.The HIV-1 coat protein gp120 and some of its fragments potently activate native cerebral NMDA receptors mediating neuropeptide release[J]. Eur J Neurosci, 2000,12(8):2839-2846.
[35] KESWANI SC, JACK C, ZHOU C, et al.Establishment of a rodent model of HIV-associated sensory neuropathy[J]. J Neurosci, 2006,26(40):10299-10304.
[36] 乐晓琴, 张仁芳. 富马酸替诺福韦二吡呋酯对艾滋病患者肾脏毒性的研究进展[J/CD]. 新发传染病电子杂志, 2018,3(3):150-152.
[37] FIELDS JA, SWINTON MK, CARSON A, et al.Tenofovir disoproxil fumarate induces peripheral neuropathy and alters inflammation and mitochondrial biogenesis in the brains of mice[J]. Sci Rep, 2019,9(1):17158.
[38] SASAKI M, KAMIYA Y, BAMBA K, et al.Serotonin Plays a Key Role in the Development of Opioid-Induced Hyperalgesia in Mice[J]. J Pain, 2021,22(6):715-729.
[39] LIU B, LIU X, TANG SJ.Interactions of Opioids and HIV Infection in the Pathogenesis of Chronic Pain[J]. Front Microbiol, 2016,7:103.
[40] PODHAIZER EM, ZOU S, FITTING S, et al.Morphine and gp120 toxic interactions in striatal neurons are dependent on HIV-1 strain[J]. J Neuroimmune Pharmacol, 2012,7(4):877-891.
[41] SHI Y, YUAN S, TANG SJ.Morphine and HIV-1 gp120 cooperatively promote pathogenesis in the spinal pain neural circuit[J]. Mol Pain, 2019,15:2069295140.
[42] AZIZ-DONNELLY A, HARRISON T B.Update of HIV-Associated Sensory Neuropathies[J]. Curr Treat Options Neurol, 2017,19(10):36.
[43] RIZZUTO N, CAVALLARO T, MONACO S, et al.Role of HIV in the pathogenesis of distal symmetrical peripheral neuropathy[J]. Acta Neuropathol, 1995,90(3):244-250.
[44] KESWANI S C, POLLEY M, PARDO CA, et al.Schwann cell chemokine receptors mediate HIV-1 gp120 toxicity to sensory neurons[J]. Ann Neurol, 2003,54(3):287-296.
[45] RODA RH, HOKE A.Mitochondrial dysfunction in HIV-induced peripheral neuropathy[J]. Int Rev Neurobiol, 2019,145:67-82.
[46] RODA RH, BARGIELA D, CHEN W, et al.Large Mitochondrial DNA Deletions in HIV Sensory Neuropathy[J]. Neurology, 2021.
[47] KESWANI SC, CHANDER B, HASAN C, et al.FK506 is neuroprotective in a model of antiretroviral toxic neuropathy[J]. Ann Neurol, 2003,53(1):57-64.
[48] SHU Y, XIANG M, ZHANG P, et al.Wnt-5a Promotes Neural Development and Differentiation by Regulating CDK5 via Ca2+/Calpain Pathway[J]. Cell Physiol Biochem, 2018,51(6):2604-2615.
[49] NUSSE R, CLEVERS H.Wnt/beta-Catenin Signaling, Disease, and Emerging Therapeutic Modalities[J]. Cell, 2017,169(6):985-999.
[50] WANG Z, LIU CH, HUANG S, et al.Wnt Signaling in vascular eye diseases[J]. Prog Retin Eye Res, 2019,70:110-133.
[51] ZHANG YK, HUANG ZJ, LIU S, et al.WNT signaling underlies the pathogenesis of neuropathic pain in rodents[J]. J Clin Invest, 2013,123(5):2268-2286.
[52] TANG J, JI Q, JIN L, et al.Secreted frizzled-related protein 1 regulates the progression of neuropathic pain in mice following spinal nerve ligation[J]. J Cell Physiol, 2018,233(8):5815-5822.
[53] ITOKAZU T, HAYANO Y, TAKAHASHI R, et al.Involvement of Wnt/beta-catenin signaling in the development of neuropathic pain[J]. Neurosci Res, 2014,79:34-40.
[54] SHI Y, YUAN S, LI B, et al.Regulation of Wnt signaling by nociceptive input in animal models[J]. Mol Pain, 2012,8:47.
[55] WOODS SP, BABICZ M, SHAHANI L, et al.Brain-derived neurotrophic factor (BDNF) is associated with depressive symptoms in older adults with HIV disease[J]. J Neurovirol, 2021,27(1):70-79.
[56] BEVERUNGEN H, KLASZKY SC, KLASZKY M, et al.Rehabilitation Decreases Spasticity by Restoring Chloride Homeostasis through the Brain-Derived Neurotrophic Factor-KCC2 Pathway after Spinal Cord Injury[J]. J Neurotrauma, 2020,37(6):846-859.
[57] BACHIS A, MAJOR EO, MOCCHETTI I.Brain-derived neurotrophic factor inhibits human immunodeficiency virus-1/gp120-mediated cerebellar granule cell death by preventing gp120 internalization[J]. J Neurosci, 2003,23(13):5715-5722.
[58] GUINDON J, BLANTON H, BRAUMAN S, et al.Sex Differences in a Rodent Model of HIV-1-Associated Neuropathic Pain[J]. Int J Mol Sci, 2019,20(5).
[59] LI Y, GUO X, SUN L, et al.N(6)-Methyladenosine Demethylase FTO Contributes to Neuropathic Pain by Stabilizing G9a Expression in Primary Sensory Neurons[J]. Adv Sci (Weinh), 2020,7(13):1902402.
[60] WINIAS S, RADITHIA D, SAVITRI ED. Neuropathy complication of antiretroviral therapy in HIV/AIDS patients[J]. Oral Dis, 2020,26 Suppl 1:149-152.
[61] MERLIN JS, BULLS HW, VUCOVICH LA, et al.Pharmacologic and non-pharmacologic treatments for chronic pain in individuals with HIV: a systematic review[J]. AIDS Care, 2016,28(12):1506-1515.
[62] EIBACH L, SCHEFFEL S, CARDEBRING M, et al.Cannabidivarin for HIV-Associated Neuropathic Pain: A Randomized, Blinded, Controlled Clinical Trial[J]. Clin Pharmacol Ther, 2021,109(4):1055-1062.
[63] CHERRY CL, WADLEY AL, KAMERMAN PR.Diagnosing and treating HIV-associated sensory neuropathy: a global perspective[J]. Pain Manag, 2016,6(2):191-199.
[64] SABBIR MG, CALCUTT NA, FERNYHOUGH P.Muscarinic Acetylcholine Type 1 Receptor Activity Constrains Neurite Outgrowth by Inhibiting Microtubule Polymerization and Mitochondrial Trafficking in Adult Sensory Neurons[J]. Front Neurosci, 2018,12:402.
[65] DI STEFANO G, DI LIONARDO A, GALOSI E, et al.Acetyl-L-carnitine in painful peripheral neuropathy: a systematic review[J]. J Pain Res, 2019,12:1341-1351.
[66] VICKERS AJ, VERTOSICK EA, LEWITH G, et al.Acupuncture for Chronic Pain: Update of an Individual Patient Data Meta-Analysis[J]. J Pain, 2018,19(5):455-474.
[67] AMANITI A, SARDELI C, FYNTANIDOU V, et al.Pharmacologic and Non-Pharmacologic Interventions for HIV-Neuropathy Pain. A Systematic Review and a Meta-Analysis[J]. Medicina (Kaunas), 2019,55(12).
[68] MKANDLA K, MYEZWA H, MUSENGE E.The effects of progressive-resisted exercises on muscle strength and health-related quality of life in persons with HIV-related poly-neuropathy in Zimbabwe[J]. AIDS Care, 2016,28(5):639-643.
[69] KUPHAL KE, FIBUCH EE, TAYLOR BK.Extended swimming exercise reduces inflammatory and peripheral neuropathic pain in rodents[J]. J Pain, 2007,8(12):989-997.
[70] STAGG NJ, MATA HP, IBRAHIM MM, et al.Regular exercise reverses sensory hypersensitivity in a rat neuropathic pain model: role of endogenous opioids[J]. Anesthesiology, 2011,114(4):940-948.
[71] YE H, Du X, HUA Q.Effects of voluntary exercise on antiretroviral therapy-induced neuropathic pain in mice[J]. J Physiol Sci, 2018,68(4):521-530.
[72] RAMIREZ-GARCIA MP, GAGNON MP, COLSON S, et al.Mind-body practices for people living with HIV: a systematic scoping review[J]. BMC Complement Altern Med, 2019,19(1):125.
[73] DORFMAN D, GEORGE MC, SCHNUR J, et al.Hypnosis for treatment of HIV neuropathic pain: a preliminary report[J]. Pain Med, 2013,14(7):1048-1056.