Analysis of pathological and clinical characteristics and factors affecting postoperative complications in surgical patients with non-small cell lung cancer with HIV infection/AIDS

doi:10.19871/j.cnki.xfcrbzz.2024.02.006

Abstract

Abstract: Objective To analyse the influencing factors of pathological and clinical characteristics and postoperative complications in patients with non-small cell lung cancer with HIV infection/AIDS. Method In this study, the pathological and clinical data of NSCLC patients with HIV infection/AIDS who underwent surgery in the Thoracic Surgery Department of Chengdu Public Health Clinical Medical Center from September 2018 to December 2022 and the pathological and clinical characteristics and risk factors of postoperative complications were analyzed. Result A total of 50 patients were included in this study, with a mean age of (56.86±8.89) years, of whom 74.00% were male and 26.00% were female. Adenocarcinoma accounted for 72.00%, and squamous carcinoma accounted for 28.00%. 29 patients underwent genetic testing and PD-L1 protein testing, and the mutation rate of EGFR was 62.06%, the mutation rate of KRAS was 17.24%, the mutation rate of BRAF was 6.90% and the mutation rate of ALK was 3.45%, and the positive rate of PD-L1 protein testing was 20.69% (6/29), and the rate of postoperative complications was 38.00% (19/50). including 14 cases of lung infection, 2 cases of pulmonary atelectasis, 1 case of pyothorax, and 2 cases of coeliac chest. The duration of preoperative antiretroviral therapy ≤4 weeks, HIV load ≥40×10³copy/L, and CD4⁺T lymphocyte count <200×10⁶/L were suggested to be independent risk factors for postoperative complications by multifactorial logistic regression analysis (P<0.05). Conclusion Maintaining a high CD4⁺T lymphocyte count and low HIV load through effective antiretroviral, it is effective in reducing postoperative complications of surgical treatment in patients with NSCLC combined with HIV infection/AIDS.

Key words: Non-small cell lung cancer, Human immunodeficiency virus, Postoperative complications, Factors

CLC Number:

R522
R654.7

Wang Ning, Li Gang, Gong Sheng, Song Yijie, Li Dan, Liu Yu, Tang Jing, Chen Zhaoqiong, Jiang Liangshuang, Yao Xiaojun. Analysis of pathological and clinical characteristics and factors affecting postoperative complications in surgical patients with non-small cell lung cancer with HIV infection/AIDS[J]. Electronic Journal of Emerging Infectious Diseases, 2024, 9(2): 29-33.

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