Analysis of the correlation between dysglycemic dyslipidemia and pulmonary tuberculosis combined with type 2 diabetes

doi:10.19871/j.cnki.xfcrbzz.2022.04.009

Abstract

Abstract: Objective To address the correlation between dysglycemic dyslipidemia and pulmonary TB combined with T2DM (pulmonary TB-T2DM) was investigated to provide new ideas for reducing the prevalence of pulmonary TB. Method A total of 330 cases, including 270 cases in the experimental group—90 patients of pulmonary TB(PTB group)、90 patients of T2DM(T2DM group) and 90 patients of pulmonary TB-T2DM(TB-T2DM group), and 60 cases of healthy subjects from outpatient physical examination in the control group, were collected from September 2020 to August 2021 in Shenzhen Center for Chronic Disease Control. After the whole blood and serum specimens were collected from the experimental and control group, the anticoagulated whole blood was tested by high performance liquid chromatography (HPLC) to determine the percentage of hemoglobin A1c (HbA1c), and serum fasting blood glucose (FBG), total cholesterol (CHOL), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) levels were measured by enzyme colorimetric method. To analyze the prediction of the level of glycemic lipid control on the prevalence of pulmonary TB. Result The T2DM group has the highest average age (57.34 ± 9.52 ), the proportion of people with poorly controlled HbA1c and FBG in both T2DM and pulmonary TB-T2DM groups was significantly higher than that in the healthy control and pulmonary TB groups (all P<0.05); pulmonary TB, T2DM and pulmonary TB-T2DM groups all had significantly higher proportions of elevated CHOL and LDL-C than controls (all P<0.05), while T2DM and pulmonary TB-T2DM groups had significantly higher proportions of elevated TG than healthy control and pulmonary TB groups (all P<0.05). Binary logistic regression shows that elevated TG（OR=2.43,95% CI：1.117~5.289,P<0.05）was independent risk factors for the prevalence of pulmonary TB. Conclusion Elevated TG is possible independent risk factor for pulmonary TB disease; Lifestyle guidance and interventions aimed to contain abnormal fluctuations in lipid profiles are recommended for middle-aged and elderly populations.

Key words: Pulmonary tuberculosis, Type 2 diabetes mellitus, Blood glucose, Blood lipid

Gui Jing, Yang Hui, Fu Yu, Liu Ta. Analysis of the correlation between dysglycemic dyslipidemia and pulmonary tuberculosis combined with type 2 diabetes[J]. Electronic Journal of Emerging Infectious Diseases, 2022, 7(4): 37-41.

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