Abstract: Objective To evaluate the value of CT in the differentiation of single nodule or mass type pulmonary tuberculosis and lung cancer, and to provide reference for the differential diagnosis of nodular or mass pulmonary tuberculosis and lung cancer. Methods A total of 60 patients with suspected lung cancer admitted to Guangzhou Chest Hospital from January 2018 to December 2019 were selected as study subjects. CT examination was performed on all patients, postoperative pathological examination was performed, and the disease detection rate and diagnostic value of the two examination methods were compared. Results Among the 60 patients with suspected lung cancer, 38 cases were nodular or mass pulmonary tuberculosis and 22 cases were lung cancer; In patients with nodular or mass pulmonary tuberculosis, 18 cases (47.37%) had lesions located in the posterior segment of the upper lobe tip, 26 cases (68.42%) had diameter less than 3cm, 27 cases (71.05%) had cavity calcification, 30 cases (78.94%) had multipoint necrosis, 26 cases (68.42%) had tortuous bronchiectasis, which was higher than that in 4 cases (18.18%), 7 cases (31.82%), 6 cases (27.27%) and 10 cases (45.45%) of lung cancer 7 cases (31.82%), the difference was statistically significant (P<0.05);Among the patients with lung cancer, 9 cases (40.91%) had blurred edges, 11 cases (45.45%) had lobulation and notch, 7 cases (31.82%) had burr, which was higher than 2 cases (5.26%), 3 cases (7.89%) and 1 case (2.68%) of nodular or mass pulmonary tuberculosis (P<0.05). The detection rate of single nodule or mass type pulmonary tuberculosis granulation by CT examination was 92.11%, and that of lung cancer was 90.91%. Compared with postoperative pathology, the data showed no no significant difference (P>0.05).The sensitivity, specificity and accuracy of CT disease diagnosis were 92.11, 90.91%, 91.67%, missed diagnosis rate 7.89%, and misdiagnosis rate 9.09%. Compared with postoperative pathology examination, there was no significant difference (P>0.05). Conclusion The imaging findings of nodular or mass pulmonary tuberculosis and lung cancer were significantly different.CT has high accuracy and high specificity in differentiating nodular or mass pulmonary tuberculosis and lung cancer. It can replace invasive examination such as needle biopsy to some extent, and provide reference for disease treatment.

Key words: X-ray computed, tomography, Nodular or mass pulmonary tuberculosis, Lung cancer, Imaging features