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Electronic Journal of Emerging Infectious Diseases ›› 2022, Vol. 7 ›› Issue (3): 32-36.doi: 10.19871/j.cnki.xfcrbzz.2022.03.007

• Original Articles • Previous Articles     Next Articles

Analysis of the effect of standard anti-TB treatment regimen on renal function in patients with MDR-TB

Fu Han1, Wang Peng1, Zhang Zonghua1, Ji Lecai2   

  1. 1. Department of Pharmacy, Shenzhen Center for Chronic Disease Control, Guangdong Shenzhen 518020,China;
    2. Department of Tuberculosis, Shenzhen Center for Chronic Disease Control, Guangdong Shenzhen 518020, China
  • Received:2022-01-16 Online:2022-07-31 Published:2022-09-08

Abstract: Objective To explore the extent of drug damage to renal function during the treatment of MDR-TB patients with a standard anti-TB regimen, and evaluate its impact on the treatment. Method The clinical data and test data of 125 MDR-TB patients treated in the Tuberculosis Department of Shenzhen Chronic Disease Prevention and Treatment Center from January 1, 2018 to December 31, 2019 were collected retrospectively, and the changes of serum creatinine, urea nitrogen and urine protein were analyzed. R software (version 3.6.2) was used for statistical processing and drawing. Result Among 125 patients, 81.6% (102/125) included injections such as amikacin in their treatment regimen, and 18.4% (23/125) did not. There were 24 patients with abnormal renal function in 102 patients with injection regimen, and 8 patients with abnormal renal function in 23 patients without injection regimen. The value of χ2 was 1.506, P=0.220. During the course of treatment, 25.6% (32/125) patients showed abnormal renal function indicators of different types: 8.0% (10/125) patients with increased urea alone, 5.6% (7/125) patients with increased serum creatinine alone, 3.2% (4/125) patients with positive urine protein alone, and 5.6%( 7/125) patients with increased urea combined with increased serum creatinine, 1.6% (2/125) patients with increased urea combined with positive urinary protein, patients with elevated serum creatinine combined with positive urinary protein were 0.8% (1/125), and those with all three abnormalities were 0.8% (1/125). The positive time of urine protein is earlier than that of urea and creatinine. According to RIFLE's diagnostic scale, 2.4% (3/125) of patients had renal impairment. Conclusion The Standard anti-tuberculosis regimen had little effect on patients' renal function during the treatment of MDR-TB, and most of the patients had transient mild abnormalities. Amikacin injection did not cause significant increase in renal injury. In the course of treatment, timely monitoring of routine urine and renal function, especially urinary protein, early detection of abnormalities and proper treatment can effectively avoid the occurrence of serious kidney injury and ensure the effective implementation of treatment regimen.

Key words: Multidrug-resistant pulmonary tuberculosis, Renal function, Anti-TB treatment regimen, Adverse drug reactions