1对夫妻境外输入性寨卡病毒共同感染病例的临床与流行病学特征分析

doi:10.19871/j.cnki.xfcrbzz.2026.03.013

新发传染病电子杂志 ›› 2026, Vol. 11 ›› Issue (3): 72-76.doi: 10.19871/j.cnki.xfcrbzz.2026.03.013

1对夫妻境外输入性寨卡病毒共同感染病例的临床与流行病学特征分析

吴延杰^1,*, 林志萍^2,*, 石晓路^3,4, 蔡健光^3,4, 龙文汀⁵, 关媛⁵, 杨莹⁵, 李杰⁶, 张晓文¹, 叶郁辉¹

1.北京大学深圳医院预防保健与医院感染管理部,广东深圳 518036;
2.福田区疾病预防控制中心消毒与病媒生物管理部,广东深圳 518000;
3.深圳市疾病预防控制中心病原微生物检验所,广东深圳 518055;
4.南方医科大学公共卫生学院,广东广州 510515;
5.北京大学深圳医院急诊科,广东深圳 518036;
6.北京大学深圳医院检验科,广东深圳 518036

收稿日期:2025-11-16 出版日期:2026-06-30 发布日期:2026-07-17
通讯作者: 叶郁辉,Email: Yuhuiye123@163.com。
作者简介:*,并列第一作者。
基金资助:
1.深圳市医学研究专项资金项目（B2404002）;2.深圳市医疗卫生“三名工程”（清华大学医学院程功教授重大媒介传染病防控研究创新团队）项目（SZSM202211023）;3.深圳市科技计划资助项目（SYSPG20241211173921049）

Clinical and epidemiological characteristics of a couple infected with Zika virus after returning from abroad in Shenzhen, China

Wu Yanjie¹, Lin Zhiping², Shi Xiaolu^3,4, Cai Jianguang^3,4, Long Wenting⁵, Guan Yuan⁵, Yang Ying⁵, Li Jie⁶, Zhang Xiaowen¹, Ye Yuhui¹

1. Department of Preventive Healthcare and Hospital Infection Control, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, China;
2. Department of Disinfection and Vector Control, Futian District Center for Disease Control and Prevention, Shenzhen, Guangdong 518000, China;
3. Institute of Pathogenic Microbiology, Shenzhen Center for Disease Control and Prevention, Guangdong Shenzhen 518055, China;
4. School of Public Health, Southern Medical University, Guangdong Shenzhen 518055, China;
5. Department of Emergency Medicine, Peking University Shenzhen Hospital, Guangdong Shenzhen 518055, China;
6. Department of Clinical Laboratory, Peking University Shenzhen Hospital, Guangdong Shenzhen 518055, China

Received:2025-11-16 Online:2026-06-30 Published:2026-07-17

摘要/Abstract

摘要： 寨卡病毒病是一种由伊蚊传播的急性病毒性传染病,临床表现以发热、皮疹、结膜炎和关节痛为主。近年来东南亚地区疫情持续活跃,我国虽偶有输入性病例报道,但夫妻共同感染者极为罕见。本文报道了深圳市发现的1对夫妻境外输入性寨卡病毒病共同感染病例,2025年9月27日至10月3日两名患者共同前往马来西亚沙巴州仙本那地区,其间均有明确蚊虫叮咬史,10月4日男性患者首先发病,主要症状为畏寒、高热、全身散在红色斑丘疹及轻度乏力,伴眼结膜轻度充血及关节酸痛。10月5日女性患者相继发病,症状相对较轻,仅表现为低热、轻度头痛,以及颈部、躯干及四肢对称分布的红色斑丘疹。实验室检测显示2例寨卡病毒核酸检测结果均为阳性,登革病毒及基孔肯雅病毒核酸检测结果均为阴性。2例患者经对症支持治疗后,症状于入院后3~5d内明显缓解,均无神经系统并发症。经流行病学调查判定,2例患者为共同暴露型输入性病例。患者所在社区及时开展蚊媒监测与防控,未发现继发病例。总结显示,夫妻共同感染寨卡病毒临床表现存在个体差异,早期识别与干预可减轻病情并有效防止本地传播,为输入性寨卡病毒病的诊治和防控提供参考。

关键词: 寨卡病毒, 输入性病例, 夫妻共同感染, 蚊媒防控, 流行病学特征, 深圳

Abstract: Zika virus disease is an acute viral infectious disease transmitted by Aedes mosquitoes, with clinical manifestations primarily including fever, rash, conjunctivitis, and arthralgia. In recent years, epidemics have remained active in Southeast Asia. Although sporadic imported cases have been reported in China, concurrent infection in a married couple is extremely rare. This article reports one pair of imported Zika virus disease cases in a married couple identified in Shenzhen. From September 27 to October 3, 2025, both patients traveled together to Semporna, Sabah, Malaysia, where they had a clear history of mosquito bites. On October 4, the male patient developed symptoms first, mainly presenting with chills, high fever, scattered red maculopapular rash over the body, and mild fatigue, accompanied by mild conjunctival congestion and joint pain. On October 5, the female patient subsequently became ill, with milder symptoms consisting only of low-grade fever, mild headache, and symmetrically distributed red maculopapular rash on the neck, trunk, and limbs. Laboratory testing showed positive Zika virus nucleic acid in both cases, while dengue virus and chikungunya virus nucleic acid tests were negative. After symptomatic and supportive treatment, the symptoms of both patients significantly improved within 3-5 days of hospitalization, with no neurological complications observed. Epidemiological investigation determined that the two cases were co-exposed imported infections. The community where the patients resided promptly implemented mosquito vector surveillance and control measures, and no secondary cases were identified. In summary, clinical manifestations of concurrent Zika virus infection in a married couple can show individual differences. Early recognition and intervention can alleviate the disease severity and effectively prevent local transmission, providing reference for the diagnosis, treatment, and prevention of imported Zika virus disease.

Key words: Zika virus, Imported infection, Couple co-infection, Vector control, Epidemiological characteristics, Shenzhen

中图分类号:

吴延杰, 林志萍, 石晓路, 蔡健光, 龙文汀, 关媛, 杨莹, 李杰, 张晓文, 叶郁辉. 1对夫妻境外输入性寨卡病毒共同感染病例的临床与流行病学特征分析[J]. 新发传染病电子杂志, 2026, 11(3): 72-76.

Wu Yanjie, Lin Zhiping, Shi Xiaolu, Cai Jianguang, Long Wenting, Guan Yuan, Yang Ying, Li Jie, Zhang Xiaowen, Ye Yuhui. Clinical and epidemiological characteristics of a couple infected with Zika virus after returning from abroad in Shenzhen, China[J]. Electronic Journal of Emerging Infectious Diseases, 2026, 11(3): 72-76.

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1对夫妻境外输入性寨卡病毒共同感染病例的临床与流行病学特征分析

Clinical and epidemiological characteristics of a couple infected with Zika virus after returning from abroad in Shenzhen, China

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