《WHO结核病综合指南模块3——诊断》解读

doi:10.19871/j.cnki.xfcrbzz.2025.04.016

新发传染病电子杂志 ›› 2025, Vol. 10 ›› Issue (4): 94-104.doi: 10.19871/j.cnki.xfcrbzz.2025.04.016

• 标准/指南/共识 • 上一篇

《WHO结核病综合指南模块3——诊断》解读

刘瑞花¹, 金慧芳², 王爱霞³, 郑伟⁴, 刘哲芳⁴, 陈琛⁵, 宋雪飞⁶, 乌力吉⁷, 王芙蓉^1,4

1.内蒙古自治区第四医院科研部,内蒙古呼和浩特 010000;
2.内蒙古自治区第四医院急诊医学科,内蒙古呼和浩特 010000;
3.内蒙古自治区第四医院监管病房,内蒙古呼和浩特 010000;
4.内蒙古自治区第四医院感染性疾病科,内蒙古呼和浩特 010000;
5.内蒙古自治区第四医院教学部,内蒙古呼和浩特 010000;
6.内蒙古自治区第四医院医学检验中心/输血科,内蒙古呼和浩特 010000;
7.内蒙古自治区第四医院医学影像科,内蒙古呼和浩特 010000

收稿日期:2025-06-28 出版日期:2025-08-31 发布日期:2025-09-18
通讯作者: 王芙蓉, Email：13347142277@163.com
基金资助:
1.首府地区公立医院2023年高水平临床专科建设科技项目（2023SGGZ107）; 2.首府地区公立医院2024年高水平临床专科建设科技项目（2024SGGZ06）; 3.2024年医学科学院公立医院联合研究项目（2024GLLH0254,2024GLLH0252）

Interpreting the WHO Consolidated Guidelines on Tuberculosis Module 3 Diagnosis

Liu Ruihua¹, Jin Huifang², Wang Aixia³, Zheng Wei⁴, Liu Zhefang⁴, Chen Chen⁵, Song Xuefei⁶, Wu liji⁷, Wang Furong^1,4

1. Department of Scientific Research, The Fourth Hospital of Inner Mongolia Autonomous Region, Inner Mongolia Hohhot 010000, China;
2. Department of Emergency Medicine, The Fourth Hospital of Inner Mongolia Autonomous Region, Inner Mongolia Hohhot 010000, China;
3. Secure Medical Ward, The Fourth Hospital of Inner Mongolia Autonomous Region, Inner Mongolia Hohhot 010000, China;
4. Department of Infectious Diseases, The Fourth Hospital of Inner Mongolia Autonomous Region, Inner Mongolia Hohhot 010000, China;
5. Department of Medical Education, The Fourth Hospital of Inner Mongolia Autonomous Region, Inner Mongolia Hohhot 010000, China;
6. Department of Laboratory Medicine, The Fourth Hospital of Inner Mongolia Autonomous Region, Inner Mongolia Hohhot 010000, China;
7. Department of Medical Imaging, The Fourth Hospital of Inner Mongolia Autonomous Region, Inner Mongolia Hohhot 010000, China

Received:2025-06-28 Online:2025-08-31 Published:2025-09-18

摘要/Abstract

摘要： 结核病（tuberculosis,TB）是由结核分枝杆菌（Mycobacterium tuberculosis,Mtb）引发的全球单一传染病导致的主要死因。WHO数据显示,全球约25%人口潜伏感染Mtb,但预防性治疗覆盖率低,且耐药问题加剧了治疗难度。为强化全球TB防治能力,WHO于2025年4月16日发布的《结核病综合指南模块3——诊断》系统性整合了Mtb感染、TB诊断及耐药性检测的循证策略,将TB诊断检测方法进行分类,并提出对HIV感染者和儿童增加多样本联检的新建议。该指南通过强化早期精准诊断与耐药精准识别,显著提升临床决策效率与治疗成功率,为落实WHO“终止结核病战略”的目标提供了重要技术支撑与政策框架。

关键词: 结核病, 耐药性, 诊断, 世界卫生组织结核病综合指南, 解读

Abstract: Tuberculosis (TB)is the infectious disease with the highest mortality rate attributable to a single pathogen,caused by Mycobacterium tuberculosis (Mtb). According to estimates by the World Health Organization (WHO), roughly one-quarter of the world's population is latently infected with Mtb; however, the proportion receiving preventive treatment remains insufficient, and drug resistance is exacerbating treatment difficulties. To bolster global TB control capabilities, the WHO has issued the Comprehensive Guidelines on Tuberculosis: Module 3—Diagnosis. This comprehensive document systematically integrates evidence-based strategies for TB infection management, diagnostic procedures, and drug-resistance testing. It classifies various TB diagnostic methods and introduces new recommendations to increase multi-sample testing, particularly for HIV-infected individuals and children.By emphasizing early, precise diagnosis and the accurate detection of drug resistance, these guidelines aim to enhance clinical decision-making and improve treatment success rates. They also provide vital technical support and policy frameworks essential for achieving the Objectives outlined in the WHO's “End TB Strategy”.

Key words: Tuberculosis, Drug Resistance, Diagnosis, WHO consolidated tuberculosis guidelines, Interpretation

中图分类号:

刘瑞花, 金慧芳, 王爱霞, 郑伟, 刘哲芳, 陈琛, 宋雪飞, 乌力吉, 王芙蓉. 《WHO结核病综合指南模块3——诊断》解读[J]. 新发传染病电子杂志, 2025, 10(4): 94-104.

Liu Ruihua, Jin Huifang, Wang Aixia, Zheng Wei, Liu Zhefang, Chen Chen, Song Xuefei, Wu liji, Wang Furong. Interpreting the WHO Consolidated Guidelines on Tuberculosis Module 3 Diagnosis[J]. Electronic Journal of Emerging Infectious Diseases, 2025, 10(4): 94-104.

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《WHO结核病综合指南模块3——诊断》解读

Interpreting the WHO Consolidated Guidelines on Tuberculosis Module 3 Diagnosis

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