Progress in the study of the pulmonary and intestinal flora and the occurrence and development of tuberculosis

doi:10.19871/j.cnki.xfcrbzz.2024.04.013

Abstract

Abstract: Tuberculosis is a chronic infectious disease caused by mycobacterium tuberculosis (mycobacterium tuberculosis, Mtb). It poses a significant threat to human health.The human lungs and intestinal tract are home to trillions of microorganisms. As a result, microbiological flora has received increasing attention in clinical research on tuberculosis. This has been achieved through summaries of relevant literature published in recent years in Pubmed, Embase, CNKI, and the Wanfang database. These summaries provide information on the composition and characteristics of lung and intestinal flora, the role of flora in tuberculosis, and the impact of tuberculosis mycobacterium treatment on the microbiota.Research has demonstrated that: the lung flora composition differs between TB patients and the healthy population; the intestinal flora's α diversity changed following Mtb infection; the immune system, the intestinal-lung axis, and host metabolites play a role in the development of tuberculosis; the structural composition of the intestinal flora is altered by treatment with anti-tuberculosis mycobacterium; "flora therapy" is a new adjuvant therapy in the field of tuberculosis. Additional research on the relationship between microbiota and tuberculosis may yield novel prevention strategies.

Key words: Pulmonary flora, Intestinal flora, Intestinal-lung axis, Tuberculosis

CLC Number:

R521.9

Liu Yu, Sun Xiaoqin, Liu Ting, Xu Yali, Hu Weidong. Progress in the study of the pulmonary and intestinal flora and the occurrence and development of tuberculosis[J]. Electronic Journal of Emerging Infectious Diseases, 2024, 9(4): 61-67.

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