Abstract: Tuberculosis (TB) during pregnancy poses a significant health threat to both the mother and the fetus/infant. Protecting maternal and child health and interrupting the mother-to-child transmission chain of TB are critical components of TB control. However, current research evidence in this field remains relatively limited. To address this gap, the guideline panel convened a multidisciplinary group of experts in tuberculosis, obstetrics and gynecology, pediatrics, infectious diseases, imaging, preventive medicine, and hospital administration. Based on the principles of evidence-based medicine and a standardized methodological framework, the panel discussed key issues in diagnosis and clinical management, aiming to develop standardized practice recommendations. This guideline covers preconception TB screening, diagnosis and treatment of gestational TB, neonatal TB assessment, breastfeeding management, and infection prevention and control measures. The guideline also addresses TB-related considerations for women with latent TB infection (LTBI) prior to conception and infertile women undergoing assisted reproductive technologies (ART), providing evidence-based solutions where available. Through expert consensus, 15 core recommendations were formulated to provide an evidence-based reference and decision-making tool for healthcare professionals involved in TB care and maternal and child health.

Key words: Tuberculosis, Mother-to-child transmission, Mycobacterium tuberculosis infection, Assisted reproductive technologies, Prevention and treatment guidelines