Abstract: Objective To analyze the epidemiological characteristics, pregnancy outcomes and the influencing factors of high exposure risk in offspring of HIV-infected pregnant women in Qingdao from 2011 to 2024, so as to provide a basis for continuously optimizing the local HIV mother-to-child transmission prevention measures. Method The individual information of HIV-infected pregnant women reported by Qingdao from January 1, 2011 to December 31, 2024 was collected from the national management information system for the prevention of mother-to-child transmission of AIDS, syphilis and hepatitis B. The epidemiological characteristics and pregnancy outcomes were described. The trend χ² test was used to analyze the changing trends of pregnancy outcomes and treatment situations. And the Cramer's V coefficient was used for evaluating the degree of correlation between variables and high exposure risk in offspring. Result 80 HIV-infected pregnant women were reported in Qingdao from 2011 to 2024. The proportions of individuals with high school education or below, engaged in housework and unemployed, registered in other provinces, and residing in urban-rural fringe areas were 76.25%, 33.75%, 46.25% and 41.25% respectively. Among the cases, 64 (80.00%) resulted in delivery, while 16(20.00%) resulted in artificial termination of pregnancy.The proportion of artificial termination of pregnancy decreased from 36.84%(7/19) to 4.00%(1/25) (trend χ²=7.347, P<0.05). Among the HIV-infected pregnant women who delivered, the proportion of those who started taking medicine before pregnancy or in the first trimester of pregnancy increased from 25.00%(3/12) to 75.00%(18/24) (trend χ²=9.450, P< 0.05). There were 10 HIV-infected pregnant women with high exposure risk in offspring. HIV-infected pregnant women who were unmarried (57.14%, 4/7) or diagnosed after the current pregnancy (33.33%,7/21) had a significantly higher proportion of high exposure risk in offspring (P<0.05). There was a moderate correlation between marital status, spouse's test status, or timing of HIV diagnosis and high exposure risk in offspring (Cramer's V values were 0.401, 0.341 and 0.310 respectively,P<0.05). Conclusion The mainly epidemiological characteristics of HIV-infected pregnant women of 2011-2024 in Qingdao include high school education or below, engaged in housework and unemployed, registered in other provinces and residing in urban-rural fringe areas. The proportion of artificial termination of pregnancy showed a significant annual decline. HIV-infected pregnant women who are unmarried or diagnosed after the current pregnancy face a higher risk of high exposure in their offspring.

Key words: HIV, Pregnant women, Epidemiological characteristics, Pregnancy outcomes, Offspring, Exposure risk, Qingdao city