A10-year retrospective investigation on the physical development of children aged18months bore by HIV-positive mothers after receiving ART of prevention of mother-to-child transmission of HIV in Nanning

doi:10.19871/j.cnki.xfcrbzz.2020.04.006

Abstract

Abstract: Objective This retrospective study aims to analyze the adverse influence on physical development of 18-month-old children born by HIV-positive mothers who received anti-retroviral therapy (ART) for prevention mother-to-child transmission (PMTCT) of HIV in past 10 years in Nanning,so as to better tailor future PMTCT medication program for providing scientific evidences.Methods Participants were divided into case group and control group based on the design of retrospective case-control study.Samples (n=1109) of the case group were annually new reported HIV-positive mothers who received ART for PMTCT and their HIV-negative infants from January 2010 to 2019 December in Nanning city.History cards and PMTCT data of participants w were obtained through the national PMTCT database.The control group included healthy mothers and their healthy infants born in 2019 (n=1778) in Nanning Maternity and Child Health Hospital.Physical development data including height,weight and head circumference of 18-month-old infants were collected.Children whose physical examination results were below the range of normal value of at least one of the three aforementioned indicators were identified as physical dysplasia.Results There were 1112 HIV-positive mothers and 1109 infants in the case group,and ART rate of PMTCT for mothers was 94.42%（1050/1112）and 96.12%（1066/1109）for kids.Rates of HIV positive,mortality and mother-to-child transmission among these children aged 18 months were respectively 0.93% (7/755),0.99%（11/1109）and 1.56%.Physical examination results indicated 17.22% (130/755) of physical dysplasia among infants aged 18 months in the case group while 9.84% (175/1778) reported in the control group.The difference between the two group showed statistically significance (P<0.001).Conclusions Potential adverse influence from ART of PMTCT on physical development of 18-month-old infants born by HIV-positive mothers that should be highly attracted attention.

Key words: Human immunodeficiency virus, Prevent mother-to-child transmission of HIV, Antiretroviral treatment, Children aged 18 Months, Physical development

Ge Xianmin, Zhu Jinhui, Jiang Wu, Lan Guanghua, Tang Chi, Li Jiangheng, Lin Qian, Chen Huanhuan, Luo Liuhong, Li Shanshan, Li Bin, Wen Pingjing, Huang Yuman, Meng Qin, Liu Shuaifeng, Wu Xiuling, Huang Jinghua, Lu Huaxiang, Deng Yueqin. A10-year retrospective investigation on the physical development of children aged18months bore by HIV-positive mothers after receiving ART of prevention of mother-to-child transmission of HIV in Nanning[J]. Electronic Journal of Emerging Infectious Diseases, 2020, 5(4): 243-248.

References

[1] 李燕.艾滋病母婴传播预防进展[J].昆明医科大学学报,2012,33(11):1-3.
[2] 吴肖冰,冯铁建,余卫业.预防控制梅毒母婴传播的关键措施及实施效果[J/CD].新发传染病电子杂志,2019,4(3):204-208.
[3] 中华医学会感染病学分会艾滋病丙型肝炎学组,中国疾病预防控制中心.中国艾滋病诊疗指南(2018版)[J/CD].新发传染病电子杂志,2019,4(2):65-84.
[4] 何云.临床医生应该如何理解《中国艾滋病诊疗指南(2018版)》[J/CD].新发传染病电子杂志,2019,4(2):125-128.
[5] 张夏燕,李萌,冯一冰,等.中国2011-2014年艾滋病母婴阻断效果的Meta分析[J].中国艾滋病性病,2015,21(4):275-279.
[7] 国家卫生健康委员会妇幼健康司.中国妇幼健康事业发展报告(2019)(一)[J].中国妇幼卫生杂志,2019,10(5):1-8.
[7] 葛宪民,杨文敏,朱秋映,等.广西壮族自治区2010–2017年艾滋病流行病学特征分析[J].中华流行病学杂志,2019,40(3):315-321.
[8] 葛宪民,杨文敏,沈智勇,等.HIV阳性母亲接受预防艾滋病母婴传播对其所生18月龄幼儿体格发育的影响[J].中华流行病学杂志,2020,41(3):354-357.
[9] 单多,王娟,孙江平,等.云南省德宏州2011-2013年预防艾滋病、梅毒和乙型肝炎母婴传播效果研究[J].中华预防医学杂志,2014,48(11):942-946.
[10] 郑敏,郭光萍,李燕,等.云南省德宏州(2014~2018)年消除艾滋病、梅毒和乙肝母婴传播效果研究[J].皮肤病与性病,2019,41(3):343-346.
[11] 覃寿学,谭健坤,施容光,等.广西部分艾滋病高流行区人类免疫缺陷病毒母婴阻断效果及及时性、依从性研究[J].第三军医大学学报,2018,40(18):1704-1710.
[12] 王爱华,谢冬华,刘智昱.2016—2017年湖南省孕产妇艾滋病疫情特征及母婴阻断情况[J].中国艾滋病性病,2018,24(11):1132-1134.
[13] 王奇,司珩,马彦民,等.河南省2002-2014年预防艾滋病母婴传播干预工作效果研究[J].河南医学研究,2017,26(9):1537-1540.
[14] 奚静,俄木阿呷,周海群,等.2008-2014年四川省凉山州某高流行县预防艾滋病母婴传播效果分析[J].现代预防医学,2016,43(16):3020-3023.
[15] 郭利芳,张晓辉,胡崇高,等.浙江省2010-2014年HIV感染孕产妇疫情及预防艾滋病母婴传播服务利用情况分析[J].中国预防医学杂志,2016,17(5):353-357.
[16] 董昱,桂希恩,唐磊,等.湖北省536例感染人类免疫缺陷病毒孕妇母婴阻断效果及影响因素分析[J].中华传染病杂志,2018,36(2):83-89.
[17] 王凤英,艾比拜•买买提明,李莉,等.2011-2012年新疆HIV母婴阻断的现况调查[J].疾病预防控制通报,2014,29(3):8-9,51.
[18] 杨梅,牟鸿江,赵鸿,等.2006-2011年贵州省预防艾滋病母婴传播效果分析[J].中国妇幼保健,2014,29(1):10-12.
[19] World Health Organization.Consolidated guideline on the use of antiretroviral drugs for treating and preventing HIV infection[M].World Health Organization.2013:67-102.
[20] UNAIDS.Fact sheet-world AIDS day 2018:2017 global HIV statistics[EB/OL].(2018-11-22])[2018-12-01].http://120.52.51.17/www.unaids.org/sites/default/files/media_asset/UNAIDS_FactSheet_en.pdf.
[21] 联合国艾滋病规划署.2020全球艾滋病防治进展报告[EB/OL].
(2020-07-07).https://www.endaids.cn/blog/2020 reportasia.
[22] 中国疾病预防控制中心性病艾滋病预防控制中心.全国艾滋病/性病/丙肝综合防治数据信息年报[R].北京:中国疾病预防控制中心性病艾滋病预防控制中心,2019年12月(总第150期).
[23] 李琎,许振宇,何艳,等.高效抗反转录病毒治疗药物对新生儿及幼儿生长发育的影响[J].中华传染病杂志,2019,37(8):473-477.
[24] 中华医学会感染病学分会艾滋病学组.艾滋病诊疗指南第三版(2015版)[J].中华临床感染病杂志,2015,8(5):385-401.
[25] 国家卫生和计划生育委员会妇幼健康服务司.预防艾滋病、梅毒和乙肝母婴传播工作实施方案(2015年版)解读[J].中国妇幼卫生杂志,2015,6(6):1-2.
[26] 刘冬梅,蒙春莲,庞俊,等.两种HAART方案预防HIV母婴传播对母婴不良影响的分析[J].广西医学,2013,35(2):201-202.
[27] 周曾全,劳云飞,陈庆玲,等.HAART预防艾滋病母婴传播的可行性和有效性[J].中国艾滋病性病,2014,20(2):76-79.
[28] 刘帅凤,邓小娥,于丽,等.76例经艾滋病母婴阻断治疗的HIV阳性孕妇产后的临床体征和免疫功能变化[J].中国艾滋病性病,2015,21(5):385-386.

[1]	Meng Zhihao, Qin Shanfang, Liu Aimei, Shen Yinzhong. Dolutegravir for rapid viral suppression in acute HIV infection [J]. Electronic Journal of Emerging Infectious Diseases, 2020, 5(3): 195-197.
[2]	Hu Zhiliang, Xu Chuanjun. Human immunodeficiency virus-associated cryptococcal immune reconstitution inflammatory syndrome [J]. Electronic Journal of Emerging Infectious Diseases, 2020, 5(2): 126-130.
[3]	YUAN Jing, LI Chun-hua, LI Qi-sui, YU Qing, LV Sheng-xiu, CHEN Yao-kai. Association between CD4⁺T cell counts and chest CT scan parameters in severely immunocompromised patients coinfected with human immunodeficiency virus and tuberculosis [J]. Electronic Journal of Emerging Infectious Diseases, 2019, 4(3): 145-148.
[4]	WU Ya-song, MA Ye. CurrentStatus of HIV drug resistance in China [J]. Electronic Journal of Emerging Infectious Diseases, 2019, 4(3): 181-184.
[5]	. Chinese guidelines for diagnosis and treatment of HIV/AIDS (2018) [J]. Electronic Journal of Emerging Infectious Diseases, 2019, 4(2): 65-84.
[6]	WANG Si-yuan, SUN Li-qing, DUAN Si-qin, SONG Ying, RAO Man, ZHOU Yang. The role of CD4/CD8 ratio in predicting clinical outcomes in human immunodeficiency virus(HIV) infected patients [J]. Electronic Journal of Emerging Infectious Diseases, 2019, 4(2): 91-96.
[7]	YUAN Hong. Clinical and imaging manifestations of AIDS complicated with intracerebral parasitic infection [J]. Electronic Journal of Emerging Infectious Diseases, 2018, 3(4): 239-243.
[8]	LI Hang, WANG Ming-yue, LU Zhi-yan. Neuroimaging of HIV-associated cryptococcal meningoencephalitis:comparison of magnetic resonance imaging findings in patients with and without highly active antiretroviral therapy [J]. Electronic Journal of Emerging Infectious Diseases, 2016, 1(1): 38-41.