Abstract: Objective To retrospectively analyze the incidence and prognosis of tuberculosis in patients with chronic kidney disease（CKD）, and to investigate the characteristics of tuberculosis in patients with CKD. Method Patients who received CKD treatment and dialysis treatment for more than 3 months in the nephrology department and blood purification center of four hospitals in Shenzhen from January 2013 to December 2017 were divided into 2 groups, ESRD group（end-stage renal disease,ESRD): glomerular filtration rate <15ml/(min·1.73m²); no-ESRD group（non-end-stage renal disease,no-ESRD): glomerular filtration rate ≥15ml/(min·1.73m²), and all patients meet the diagnostic criteria for CKD. The incidence, clinical features and prognosis of tuberculosis in these patients were retrospectively analyzed. Result There were 1169 and 3026 patients in the ESRD group and no-ESRD group respectively. Fifty-seven patients (4.9%) with active pulmonary tuberculosis were diagnosed in the ESRD group,of which 36 patients (63.2%) with pulmonary tuberculosis, 14 patients (24.6%) with extrapulmonary tuberculosis, 7 patients (12.3%) with pulmonary tuberculosis complicated extrapulmonary tuberculosis. The all-cause mortality rate was 8.8% (5/57) in the ESRD group. Sixty-nine patients (2.3%) with active tuberculosis were diagnosed in the no-ESRD group, of which 47 patients (68.1%) with pulmonary tuberculosis, 16 patients (23.2%) with extrapulmonary tuberculosis, and 6 patients (8.7%) with pulmonary tuberculosis complicated extrapulmonary tuberculosis.The all-cause mortality rate was 2.9% (2/69) in the no-ESRD group. Comparing the two groups of ESRD and no-ESRD, the incidence and etiology distribution are statistically significant (χ²=19.502、10.076,P=0.000、0.018); But there was no statistical difference between the two groups in immunological detection, tuberculosis type, and clinical prognosis (χ²=0.222、0.530、3.971,P=0.974、0.767、0.137). Conclusion The incidence of tuberculosis in patients with CKD is high, especially in ESRD patients. There is an urgent need screening tuberculosis for timely diagnosis and treatment in patients with CKD.

Key words: Hemodialysis, Peritoneal dialysis, Renal insufficiency, Tuberculosis, Extrapulmonary tuberculosis, Prognosis