深圳地区猴痘患者的流行病学及临床特征分析

doi:10.19871/j.cnki.xfcrbzz.2023.04.001

摘要/Abstract

摘要： 目的本研究旨在明确深圳地区猴痘患者的流行病学及临床特征。方法回顾性分析2023年6月9日至7月18日期间于深圳市第三人民医院住院治疗的49例猴痘患者临床特征及血液分析结果、超声检查等资料。采集流行病学信息,对人口学特征、临床表现、实验室检查结果、并发症、治疗和预后数据进行总结。结果 49例患者经PCR检测猴痘病毒（MPXV）阳性100%（49/49）,所有患者均为男性（49/49）。中位年龄为29岁（21~48岁）。49例患者中45例为男男性接触人群（91.84%）,2例为双性恋。平均住院时间为6.55d,平均潜伏期为8.64d。30例为合并HIV感染者（61.2%),17例合并梅毒（34.69%）,1例合并淋巴瘤（2.04%）,4例合并肛周脓肿（8.16%）。合并HIV感染的猴痘患者,有90%（27/30）接受了抗反转录病毒药物治疗（ART）。所有患者均出现皮疹,分布于肛门和生殖器（38/49,77.55%）、躯干和四肢（34/49,69.39%）、颜面部（19/49,38.79%）、足底和手掌(2/49,4.08%）,淋巴结肿大的部位为腹股沟（43/49,87.76%）、颈部（36/49,73.5%）、腋窝（26/49,53.06%）、锁骨上窝（5/49,10.2%）。非HIV感染的人群出现发热症状及肛门和生殖器出现皮疹的比例均比HIV感染人群更高（均 P<0.05）。结论深圳地区猴痘的传播流行以男男性接触人群占大多数,所有患者病情均较轻,非HIV感染的人群发热、肛门和生殖器出现皮疹的比例更高。

关键词: 猴痘, 流行病学, 临床特征, 男男性接触人群, 并发症

Abstract: Objective This study aims to clarify the epidemiological and clinical characteristics of monkeypox in Shenzhen. Method Retrospective analysis of the clinical characteristics, blood analysis results, ultrasound examination, and other data of 49 monkeypox patients hospitalized at Shenzhen Third People's Hospital from June 9 to July 18, 2023. Collect epidemiological information and summarize demographic characteristics, clinical manifestations, laboratory examination results, complications, treatment, and prognosis data. Result All of these patients were monkeypox virus-positive (49/49, 100%) by PCR test, and all the patients were men (49/49, 100%). The patients were relatively young, with a median age of 29 (21～48) years, and an average age of 30. 45 out of 49 patients were male sexual contacts (91.84%), and two were bisexual (4.08%). The average time of hospitalization was 6.55 days, and the average incubation period was 8.64 days. Among these patients, 30 were with HIV infection（61.2%), 17 were with syphilis (34.69%), 1 was with lymphoma (2.04%) and 4 were perianal abscess (8.16%). 90% (27/30) of monkeypox patients with HIV infection received anti-retroviral therapy (ART). All patients presented with skin rash, which mainly affected the anus and genitals (38/49, 77.55%), trunk and limbs (34/49, 69.39%), face (19/49, 38.79%), soles and palms (2/49, 4.08%). Most patients had lymphadenopathy in the groin (43/49, 87.76%), neck (36/49, 73.5%), armpit (26/49, 53.06%), and supraclavicular fossa (5/49, 10.2%). The proportion of fever and rash in anal genital in non-HIV infected cases is significantly higher than that in HIV-infected cases (P＜0.05). Conclusion Our study showed that transmission of monkeypox in Shenzhen was found mainly in the MSM population. Monkeypox is generally mild in this study. Cases without HIV-infected have a higher proportion of fever and rash in anal and genital.

Key words: Monkeypox, Epidemiology, Clinical characteristics, Men who have sex with men, Complications

中图分类号:

R511

陈楚明, 吴伟波, 彭凌, 曹孟丽, 冯世艳, 李建明, 杨柳青, 林元龙, 易云兰, 吴展慧, 王福祥, 卢洪洲. 深圳地区猴痘患者的流行病学及临床特征分析[J]. 新发传染病电子杂志, 2023, 8(4): 1-5.

Chen Chuming, Wu Weibo, Peng Ling, Cao Mengli, Feng Shiyan, Li Jianming, Yang Liuqing, Lin Yuanlong, Yi Yunlan, Wu Zhanhui, Wang Fuxiang, Lu Hongzhou. Epidemiological and clinical characteristics of monkeypox in Shenzhen[J]. Electronic Journal of Emerging Infectious Diseases, 2023, 8(4): 1-5.

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