新型冠状病毒肺炎患者胸部CT特征与临床严重程度相关性的Meta分析

doi:10.19871/j.cnki.xfcrbzz.2021.03.006

摘要/Abstract

摘要： 目的分析新型冠状病毒肺炎患者的胸部CT特征同肺炎临床严重程度的关系,为新型冠状病毒肺炎的筛查和诊断提供依据。方法选择“Embase”“PubMed”“Cochrane Library”数据库进行检索,检索时间为2019年12月27日至2020年12月1日,输入新型冠状病毒肺炎的关键词进行检索,入选文献的标准为在同一篇胸部CT研究文献中包括非重型和重型患者,数据统计内容包括胸部CT病灶分布、病灶成分、征象、纵隔及胸膜受累的情况。数据收集后使用Stata 12.0软件进行数据分析。结果入选23篇文献,共4105例患者,非严重组2639例,严重组1466例。严重组和非严重组相比,严重组更容易出现的CT特征为：实性病灶、实性病灶与磨玻璃病灶并存、铺路石征、支气管充气征、支气管壁增厚、牵连性支气管扩张、胸膜下线、血管增粗、纵隔淋巴结肿大、双侧分布、中央型分布、胸膜下和中央型分布并存、右肺上叶、右肺中叶、右肺下叶、左肺下叶分布;非严重组更容易出现的CT征象为结节灶,严重组和非严重组无明显差异的CT征象包括磨玻璃病灶、小叶间隔增厚、网状改变、胸膜下分布、左肺上叶分布。结论病灶分布、病灶成分、CT征象在新型冠状病毒肺炎非严重组和严重组间具有显著差异,严重组更易出现实性病灶、磨玻璃与实性混合型病灶、铺路石征、血管增粗等征象。

关键词: 新型冠状病毒, 肺炎, 体层摄影术, X线计算机, Meta分析

Abstract: Objective Meta analysis was used to explore the relationship between chest CT features and clinical severity of 2019 novel coronavirus pneumonia, so as to provide basis for screening and diagnosis of 2019 novel coronavirus pneumonia patient. Methods "Embase" "PubMed" "Cochrane Library" was retrieved from December 27, 2019 to December 1, 2020, and the key words of 2019 novel coronavirus pneumonia were searched. The standard of the selected papers was in the same chest CT research literature, including non severe and severe patients. The data included chest CT lesion distribution, lesion composition, signs, mediastinum and pleural involvement. After data collection, Stata 12.0 software was used for data analysis. Results A total of 4105 people, 2639 in the non severe group and 1466 in the severe group were included in 23 articles. The statistical results showed that the CT features more likely occured in severe group were: consolidation, coexistence of ground glass opacity and consolidation, crazy-paving pattern, air bronchogram, bronchial wall thickening,traction bronchiectasis,parenchymal band,vascular enlargement, lymphadenopathy,bilateral distribution, central distribution, coexistence of peripheral and central distribution,right upper lobe, right middle lobe, right lower lobe and left lower lobe distribution. The non severe group was more likely to have nodules, while the severe group and the non severe group had no significant difference in CT signs, including ground glass opacity, interlobular septal thickening, reticular sign, peripheral distribution and left upper lobe distribution. Conclusion Lesion distribution, lesion composition and CT signs were different in non severe group and severe group of 2019 novel coronavirus pneumonia. In severe group, there were more consolidationlesions, ground glass opacity and consolidation mixed lesions, crazy-paving pattern, vascular enlargement, pleural effusion and so on.

Key words: 2019 novel coronavirus, Pneumonia, Tomography, X-ray computed, Meta analysis

殷润, 郗艳, 刘新疆, 方慧. 新型冠状病毒肺炎患者胸部CT特征与临床严重程度相关性的Meta分析[J]. 新发传染病电子杂志, 2021, 6(3): 193-197.

Yin Run, Xi Yan, Liu Xinjiang, Fang Hui. Meta analysis of correlation between chest CT features and clinical severity of 2019 novel coronavirus pneumonia patient[J]. Electronic Journal of Emerging Infectious Diseases, 2021, 6(3): 193-197.

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