生殖道B族链球菌定植对妊娠晚期孕妇阴道微生态、血清炎症因子水平及母婴结局的影响

doi:10.19871/j.cnki.xfcrbzz.2026.02.011

新发传染病电子杂志 ›› 2026, Vol. 11 ›› Issue (2): 56-60.doi: 10.19871/j.cnki.xfcrbzz.2026.02.011

生殖道B族链球菌定植对妊娠晚期孕妇阴道微生态、血清炎症因子水平及母婴结局的影响

王春文¹, 包雪冰¹, 施建莹¹, 杨琨¹, 罗琳玲², 周倩倩², 聂潘荣¹

1.云南省保山市人民医院新生儿科,云南保山 678000;
2.云南省保山市人民医院产科,云南保山 678000

收稿日期:2025-07-28 出版日期:2026-04-30 发布日期:2026-05-18
通讯作者: 聂潘荣 Email：18087509366@163.com
基金资助:
云南省保山市医学研究联合专项面上项目（2023bskjylms003）

Effects of group B streptococcus colonization in genital tract on vaginal microecology, serum levels of inflammatory factors and maternal and infant outcomes in late pregnancy

Wang Chunwen¹, Bao Xuebing¹, Shi Jianying¹, Yang Kun¹, Luo Linling², Zhou Qianqian², Nie Panrong¹

1. Department of Neonatology, Baoshan People's Hospital, Yunnan Baoshan 678000, China;
2. Department of Obstetrics, Baoshan People's Hospital, Yunnan Baoshan 678000, China

Received:2025-07-28 Online:2026-04-30 Published:2026-05-18

摘要/Abstract

摘要： 目的探讨妊娠晚期孕妇生殖道B族链球菌（group B streptococcus,GBS）定植对阴道微生态指标、血清炎症因子水平及母婴结局的影响,为孕妇GBS筛查及防治提供参考。方法回顾性分析2022年1月至2024年12月期间在云南省保山市人民医院分娩并行阴道分泌物GBS检测的6010例妊娠晚期孕妇的临床资料,根据GBS检测结果分为GBS阳性组和GBS阴性组。比较两组临床资料、阴道微生态指标、血清炎症因子水平、母婴结局,采用多因素Logistic回归分析妊娠晚期孕妇生殖道GBS定植的影响因素。结果纳入的6010例妊娠晚期孕妇中GBS定植阳性253例,阳性率为4.21%。GBS阳性组合并妊娠糖尿病、甲状腺功能异常、阴道清洁度Ⅲ~Ⅳ级、pH值>4.5、阴道菌群分布失调比例均高于GBS阴性组（均P<0.05）;GBS阳性组血清C反应蛋白、肿瘤坏死因子α、白介素-6、白介素-1β、降钙素原水平均高于GBS阴性组（均P<0.05）。GBS阳性组孕妇分娩的新生儿呼吸窘迫综合征、高胆红素血症、化脓性脑膜炎、新生儿GBS感染发生率均高于GBS阴性组孕妇分娩的新生儿（均P<0.05）。结论妊娠晚期生殖道GBS定植可引发孕妇阴道微生态失调,加重炎症反应,增加母婴不良结局风险。

关键词: 妊娠晚期, B族链球菌, 阴道微生态, 炎症因子, 母婴结局

Abstract: Objective To investigate the effects of reproductive tract Group B streptococcus (GBS) colonization in genital tract on vaginal microecology, serum inflammatory factors and maternal and infant outcomes in late pregnant women. To provide a basis for GBS screening and prevention in pregnant women. Method The clinical data of 6010 cases late pregnant women who delivered in Baoshan People's Hospital from January 2022 to December 2024 and underwent vaginal secretions GBS detection were retrospectively analyzed. According to the GBS test results, the patients were divided into GBS positive group and GBS negative group. The baseline data, vaginal microecological indexes, serum inflammatory factors and maternal and infant outcomes were compared between the two groups. Multivariate logistic regression was used to analyze the influencing factors of GBS colonization in genital tract of late pregnant women. Result Among the 6010 cases late pregnant women, 253 cases were positive for GBS colonization, with a positive rate of 4.21%. The proportions of gestational diabetes mellitus and, thyroid dysfunction, vaginal cleanliness grade Ⅲ-Ⅳ, pH value >4.5, and the distribution of vaginal microbiota in GBS positive group were higher than those in GBS negative group (all P<0.05); The levels of C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-1β (IL-1β), procalcitonin (PCT) in GBS positive group were higher than those in GBS-negative group (all P<0.05) . The incidence rates of neonatal respiratory distress syndrome, hyperbilirubinemia, suppurative meningitis and neonatal GBS infection were higher than those in GBS-negative group (P<0.05). Conclusion GBS colonization in genital tract can cause vaginal microecological imbalance, aggravate inflammatory reaction, and increase the risk of adverse maternal and infant outcomes in late pregnant women.

Key words: Late pregnancy, Group B streptococcus, Vaginal microecology, Inflammatory factors, Maternal and infant outcomes

中图分类号:

R515
R714

王春文, 包雪冰, 施建莹, 杨琨, 罗琳玲, 周倩倩, 聂潘荣. 生殖道B族链球菌定植对妊娠晚期孕妇阴道微生态、血清炎症因子水平及母婴结局的影响[J]. 新发传染病电子杂志, 2026, 11(2): 56-60.

Wang Chunwen, Bao Xuebing, Shi Jianying, Yang Kun, Luo Linling, Zhou Qianqian, Nie Panrong. Effects of group B streptococcus colonization in genital tract on vaginal microecology, serum levels of inflammatory factors and maternal and infant outcomes in late pregnancy[J]. Electronic Journal of Emerging Infectious Diseases, 2026, 11(2): 56-60.

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生殖道B族链球菌定植对妊娠晚期孕妇阴道微生态、血清炎症因子水平及母婴结局的影响

Effects of group B streptococcus colonization in genital tract on vaginal microecology, serum levels of inflammatory factors and maternal and infant outcomes in late pregnancy

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