Abstract: This article reported a case of AIDS with multiple infection. The patient was a middle-aged man with AIDS who went to a local hospital for treatment due to symptoms such as cough, sputum and fever, and was transferred to Guiyang Public Health Treatment Center Infection Department after HIV preliminary screening and positive confirmation. After a series of examinations, the patient was initially diagnosed as AIDS combined with lung infection, and the condition did not improve significantly after antibacterial treatment. After multiple sputum culture, fiber bronchoscopeand other examinations, and sent to the alveolar lavage fluid for mNGS detection, the final diagnosis was clearly diagnosed as AIDS complicated with nocardia (nocardia abscess), pseudomonas aeruginosa infection, cytomegalovirus encephalitis. The antiinfective therapy regimen and antiretroviral therapy regimen were adjusted, and the patient improved and was discharged. This case highlights the ability of HIV to attack the human body and organs, which is an important reason for patients with multiple infections and worsening disease. It is not uncommon for people with AIDS to co-exist with other infections, so accurate diagnosis and timely treatment are essential. Through the review of the treatment experience of this case, we hope to strengthen the clinical doctors' ability to diagnose the co-infection of AIDS patients, improve the treatment effect and prolong the life of patients.

Key words: Acquired immune deficiency syndrome, Nocardiosis, Pseudomonas aeruginosa infection, Cytomegalovirus encephalitis, Metagenomics next-generation sequencing detection, Antiretroviral therapy