Abstract: Pertussis is a respiratory infectious disease caused by Bordetella pertussis infection, which is one of the Class B infectious diseases in the national notifiable infectious diseases., 60-70s of the 20th century,the incidence of whooping cough in China was very high, reaching 10-20/10 000, which brought a huge threat to people's health and life safety. Since 1978, when pertussis vaccine was widely administered nationwide, the incidence and mortality of pertussis have dropped significantly. However, according to the latest national epidemic data on notifiable infectious diseases released by the National Bureau of Disease Control and Prevention, whooping cough has made a comeback in recent years. The incidence of older children is increasing year by year, and the infection rate of young infants is also on the rise, and the infection symptoms of young infants are severe, and serious complications such as suffocation and cardiac arrest and even death may occur, which greatly affects the health and life safety of children. Based on clinical cases, this article systematically expounds the current situation of pertussis, the main clinical manifestations, diagnosis, the selection principles of treatment regimens, and vaccination and preventive measures, which has important guiding significance for clinical work.

Key words: Pertussis, Epidemiology, Diagnosis and treatment, Prevention