Abstract: Objective This systematic review summarizes the literatures on the patients with COVID-19-HIV co-infection, in order to provide references for the scientific research and the prevention or management of patients with COVID-19-HIV co-infection. Methods the literatures published from December 1, 2019 to August 11, 2020 were searched and demographics, the clinical characteristics and adverse prognostic factors of the patients with COVID-19-HIV co-infection were analyzed. Results 38 studies provided specific information on COVID-19 patients living with HIV. A total of 546 COVID-19-HIV co-infected patients were analyzed in this systematic review, of which 77.1% were male. Hypertension (40.1%) and diabetes (22.3%) were the most common comorbidities in patients with COVID-19-HIV co-infection, and the combination of these two diseases were associated with poor prognosis (P=0.016, P=0.011). Additionally, the mortality in patients aged 50 and older was significantly higher than that in those under 50 years old (P=0.002). Conclusions The clinical characteristics and risk factors on poor prognosis in patients with COVID-19-HIV co-infection are similar to that in general population. To date, there is no specific evidence that patients with COVID-19-HIV co-infection have a higher incidence or worse prognosis than general population, and it is not clear that whether the immunosuppressive status or the history of antiretroviral use in patients with COVID-19-HIV co-infection will reduce their mortality risk from COVID-19.The issue of COVID-19-HIV co-infection warrants further investigation.

Key words: Human immunodeficiency virus, Coronavirus disease 2019, Literature analysis