A comparative study on the clinical efficacy of different splenic artery embolization procedures in the treatment of hypersplenism in patients with hepatitis B liver cirrhosis

doi:10.19871/j.cnki.xfcrbzz.2026.03.003

Abstract

Abstract: Objective To compare the clinical efficacy of partial splenic embolization (PSE), main splenic artery embolization (MSAE), and combined MSAE plus PSE in the treatment of hypersplenism secondary to hepatitis B-related cirrhosis, so as to provide evidence for optimizing interventional strategies for hypersplenism. Method A retrospective analysis was performed on 85 patients with hepatitis B cirrhotic hypersplenism who received interventional embolization therapy in Shenzhen Third People's Hospital from January 2023 to April 2025. Patients were divided into three groups according to different surgical procedures: group A (n=22) underwent PSE alone, group B (n=33) underwent MSAE alone, and group C (n=30) underwent combined MSAE and PSE. The operative success rate, dynamic changes in peripheral blood three-line cell counts at different postoperative time points, and incidence of procedure-related adverse reactions were compared among the three groups. Result The operative success rate was 100% in all three groups. At 1 month postoperatively, white blood cell and platelet counts in all three groups were significantly higher than preoperative levels (P<0.05), and the elevation magnitude of platelet count in group C was significantly greater than that in group A and group B (P<0.05). At 2-month follow-up, white blood cell count in group A remained significantly higher than baseline (P<0.05), while red blood cell and platelet counts in group C remained significantly elevated compared with preoperative levels (P<0.05). In addition, the incidence of postoperative splenic artery occlusion in group B and group C was significantly higher than that in group A (P<0.05). Conclusion All three interventional embolization procedures can effectively improve thrombocytopenia and leukopenia induced by hypersplenism in the short term. Conclusion All three interventional embolization procedures can effectively improve thrombocytopenia and leukopenia induced by hypersplenism in the short term. Combined MSAE plus PSE achieves superior efficacy in elevating and maintaining platelet counts.

Key words: Viral hepatitis type B, Liver cirrhosis, Hypersplenism, Partial splenic embolization, Main splenic artery embolization, Interventional radiological embolization therapy

CLC Number:

Liu Wenhao, Zhou Yun, Xiao Liang, Kang Zhilong, Huang Xiangrong, Wang Mingbo, Feng Kai, Yang Gendong, Huang Hua. A comparative study on the clinical efficacy of different splenic artery embolization procedures in the treatment of hypersplenism in patients with hepatitis B liver cirrhosis[J]. Electronic Journal of Emerging Infectious Diseases, 2026, 11(3): 13-18.

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