A case report and literature review of systemic lupus erythematosus complicated with thigh tuberculosis, rifampin-resistant pulmonary tuberculosis and deep vein thrombosis

doi:10.19871/j.cnki.xfcrbzz.2025.01.017

Abstract

Abstract: Systemic lupus erythematosus (SLE), as an autoimmune disease, is commonly treated with a standard regimen that includes corticosteroids and immunomodulatory agents such as cyclophosphamide and methotrexate. These medications can weaken the patient's immune system, thereby increasing the risk of infectious diseases, particularly infection with Mycobacterium tuberculosis. This article reports a case of a patient with SLE who developed rifampicin-resistant pulmonary tuberculosis (RR-PTB), thigh tuberculosis, and deep vein thrombosis (DVT) during anti-tuberculosis treatment. A retrospective analysis of the patient's clinical characteristics, diagnosis, treatment, and nursing experience is presented. The patient's condition was effectively controlled through a multidisciplinary treatment approach, including early and precise anti-tuberculosis treatment, vascular intervention, postoperative rehabilitation, and nursing care. After 3 months of outpatient follow-up, the patient's tuberculosis improved and there was no recurrence of the thrombosis. A review of the literature summarized the risk factors for SLE combined with tuberculosis and DVT, emphasizing the importance of early diagnosis and standardized treatment. This case highlights the need to be vigilant for the possibility of multiple diseases in SLE patients, and the benefits of a multidisciplinary approach to diagnosis, treatment, and nursing care in improving patient prognosis.

Key words: Systemic lupus erythematosus, Rifampicin-resistant pulmonary tuberculosis, Thigh tuberculosis, Deep vein thrombosis, Literatures review

CLC Number:

R521
R519

Tang Ling, Tang Yang, Tan Jiarong, Liao Xiaogang, Li Tongxin, Yang Song. A case report and literature review of systemic lupus erythematosus complicated with thigh tuberculosis, rifampin-resistant pulmonary tuberculosis and deep vein thrombosis[J]. Electronic Journal of Emerging Infectious Diseases, 2025, 10(1): 86-90.

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