Abstract: At present, the incidence of pulmonary tuberculosis and extrapulmonary multiple tuberculosis is still high, but the diagnosis rate of extrapulmonary tuberculosis is still low. Osteoarticular tuberculosis is secondary to pulmonary tuberculosis, and the incidence of lumbar tuberculosis is the highest, which is manifested by kyphotic deformity, paravertebral abscess and bone destruction. The occurrence of intracranial tuberculosis is mostly caused by the spread of mycobacterium tuberculosis into the brain through blood, which is divided into meningeal and cerebral parenchyma tuberculosis. Prostatic tuberculosis of genitourinary system is relatively rare, imaging and clinical manifestations lack specificity, and diagnosis is difficult. This study retrospectively analyzed the diagnosis and treatment of rare prostatic hyperplasia with prostatic tuberculosis in a 67-year-old man with multiple tuberculosis of the lumbar spine and intracranial. The patient came to the clinic due to increased nocturnal urination and difficulty in urination for 1 year, aggravation for 2 months, and no previous history of fever and tuberculosis. In the early stage, prostate cancer with distant metastasis was highly suspected combined with clinical and imaging examination, and finally prostate tuberculosis was confirmed by pathological biopsy. The following report is made in order to improve the diagnosis and treatment of extrapulmonary tuberculosis and reduce missed diagnosis and misdiagnosis.

Key words: Prostatic tuberculosis, Tuberculosis of lumbar spine, Intracranial tuberculosis, Anti-tuberculosis therapy, Prostate cancer