The rs1801133 locus of MTHFR was significantly associated with multiple solid small nodules in the lung

doi:10.19871/j.cnki.xfcrbzz.2024.05.007

Abstract

Abstract: Objective To understand the relationship between multiple solid small nodules in the lung and the single nucleotide polymorphism loci (SNP) of lung cancer susceptibility genes. Exploring risk markers for early-stage lung cancer. Method Urban residents aged 40-74 were recruited to undergo low-dose spiral computed tomography of the lungs from June 2017 to October 2018. The population with multiple pulmonary small nodules was selected as the positive group, and the patients without pulmonary lesions were selected as the negative control group. There were 14 SNPs loci associated with lung cancer susceptibility were detected separately. The distribution of SNPs between the two groups and their association with multiple solid small nodules in the lungs were analyzed. Result The genotyping results showed that only the rs1801133 locus of the methylenetetrahydrofolate reductase (MTHFR) gene was significantly different in the genotype frequency distribution between cases and controls (P=0.027). The risk of multiple solid small nodules in the lungs was lower in those with AA genotype than those with GG genotype （OR=0.45,95%CI：0.23-0.57,P=0.017）. And the risk of multiple small nodules showed a decreasing trend (P_trend=0.008). In addition, the results of the dominant model analysis showed that the population carrying the AA+AG genotype had a lower risk of developing multiple solid small nodules in the lung than the population carrying the GG genotype (OR=0.59,95%CI：0.39-0.90,P=0.014). Conclusion We found that MTHFR rs1801133 was significantly associated with multiple solid small pulmonary nodules.

Key words: Multiple solid small nodules, Single nucleotide polymorphism, Association analysis, Lung nodules, Methylenetetrahydrofolate reductase

CLC Number:

R529.9

Mo Junluan, Liu Jinhong, Lei Lin, Zheng Kexin, Dai Juanxiu, Yin Jiye, Liu Zhaoqian, Li Xi, Liang Xiongshun, Hong Wenxu. The rs1801133 locus of MTHFR was significantly associated with multiple solid small nodules in the lung[J]. Electronic Journal of Emerging Infectious Diseases, 2024, 9(5): 36-41.

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