Abstract: Objective To explore the value of sound touch elastography(STE) in diagnosing non-alcoholic fatty liver disease (NAFLD) complicated with chronic hepatitis B (CHB) and identifying the Diagnostic efficacy of STE for staging the degree of liver fibrosis in this combination. Method A total of 74 NAFLD patients and 142 NAFLD patients complicated with CHB who were selected from January 2018 to January 2023 were included in the NAFLD group and NAFLD complicated with CHB group, respectively. NAFLD complicated with CHB group were classified as stage S1, stage S2, stage S3, and stage S4 according to the METAVIR grading criteria. 61 healthy volunteers were selected and included in the control group. All subjects accepted liver STE and liver STQ examinations. Compare the three groups and draw the receiver operator characteristic curve (ROC). Result There was significant difference in liver STE and liver STQ among the three groups (P<0.001). The area under the curve (AUC) of liver STE and liver STQ between control group and NAFLD complicated with CHB group was 0.834 and 0.805, the AUC between control group and NAFLD group was 0.628 and 0.617, and the AUC between NAFLD complicated with CHB group and NAFLD group was 0.741 and 0.715. The AUC of liver STE in diagnosing NAFLD complicated with CHB ≥S1, ≥S2, ≥S3 liver fibrosis and S4 cirrhosis were 0.834, 0.889, 0.940, 0.950 respectively. Conclusion There were differences in liver stiffness measurement (LSM) among NAFLD complicated with CHB, NAFLD and normal liver. Liver STE can distinguish NAFLD complicated with CHB Group from control group and NAFLD group, it has great value in the diagnosis of liver fibrosis in patients suffered NAFLD complicated with CHB.

Key words: Non-alcoholic fatty liver disease, Chronic hepatitis B, Sound touch elastography, Sound touch quantify