Abstract: Objective To analyze the epidemic law of influenza virus in Shenzhen from 2014 to 2022,study the epidemiological characteristics of influenza virus during the epidemic period, and provide the basis for formulating the comprehensive prevention and control measures of influenza. Method According to the number of permanent residents at the end of the year published by Shenzhen Municipal Bureau of statistics, the weekly influenza incidence rate of the whole population from 36th week of 2014 to the 35th week of 2022 was calculated. The epidemic law of influenza virus in Shenzhen was analyzed by using the moving epidemic method, and the epidemic intensity and population characteristics of influenza virus during the epidemic period were studied by using the epidemiological. Result Six of the eight surveillance cycles in Shenzhen 2014-2022 entered the influenza virus epidemic period, mainly in winter, spring and summer, the peak incidence rate showed an increasing trend year by year (χ²_trend=28 958.392, P<0.001). There were differences in the cumulative weeks of epidemic intensity exceeding the threshold of epidemic period in each district(χ²=100.634,P<0.001), Among the six monitoring cycles with epidemic periods, Nanshan District was the first enter the epidemic period, and the epidemic duration was longest in five monitoring cycles. Children under 14 years old were the main population(accounting for 69.5%),mainly students and nursery children. Conclusion The epidemic law of influenza virus in Shenzhen is obviously seasonal, and presents certain regional differences. Nanshan District enter the epidemic period first and the duration is often longer. In the follow-up, comprehensive and in-depth analysis should be made in combination with climate change, pathogenic changes, vaccination and population flow rules.

Key words: Influenza, Seasonality, Epidemic intensity, Characteristics analysis