HBeAg状态对HBV/TP重叠感染患者细胞免疫功能的分析

doi:10.19871/j.cnki.xfcrbzz.2021.04.007

摘要/Abstract

摘要： 目的比较不同乙肝病毒e抗原（HBeAg）水平的HBV/TP重叠感染患者的细胞免疫功能,进一步了解HBV/TP重叠感染患者细胞免疫功能变化。方法回顾性分析2019年1月至2020年1月成都市双流区第一人民医院收治的79例HBV/TP重叠感染患者的临床及实验室资料,根据治疗前HBeAg不同状态分为两组,其中HBeAg阳性组41例,HBeAg阴性组38例。对比两组患者外周血HBV-DNA水平、T淋巴细胞亚群水平以及T细胞相关细胞因子水平。结果 HBeAg阳性组HBV-DNA水平明显高于HBeAg阴性组（P<0.05）;HBeAg阳性组CD3⁺T、CD4⁺T淋巴细胞、CD4⁺T/CD8⁺T比值、自然杀伤（NK）细胞水平高于HBeAg阴性组（P<0.05）,CD8⁺T淋巴细胞水平低于HBeAg阴性组（P<0.05）;HBeAg阳性组干扰素-γ（IFN-γ）、肿瘤坏死因子（TNF-α）、白细胞介素-2（IL-2）、白细胞介素-6（IL-6）、白细胞介素-17（IL-17）、转化生长因子-β（TGF-β）水平明显高于HBeAg阴性组（P<0.05）,HBeAg阳性组白细胞介素-4（IL-4）和白细胞介素-10（IL-10）水平与HBeAg阴性组对比无明显差异（P>0.05）。结论 HBeAg水平影响HBV/TP重叠感染患者的免疫功能,可能诱导机体启动细胞免疫,提高T淋巴细胞亚群水平,促进分泌相关细胞因子。

关键词: 乙肝病毒e抗原, 乙型肝炎病毒, 梅毒螺旋体, 重叠感染, 细胞免疫功能

Abstract: Objective To compare the cellular immune function of patients with hepatitis B virus/Treponema pallidum (HBV/TP) superinfection with different hepatitis B virus e antigen (HBeAg) status, and to further understand the changes of cellular immune function in patients with HBV/TP coinfection. Methods The clinical data of 79 patients with HBV/TP superinfection admitted to our hospital from January 2019 to January 2020 were retrospectively analyzed. All patients were divided into 2 groups according to the different HBeAg status before treatment, 41 HBeAg-positive patients were included in the HBeAg-positive group, and 38 HBeAg-negative patients were included in the HBeAg-negative group. The levels of HBV-DNA, T cell-related cytokines and T lymphocyte subsets in the peripheral blood of the two groups were compared. Results The level of HBV-DNA in the HBeAg-positive group was substantially higher than that in the HBeAg-negative group (P<0.05). The levels of CD3⁺T, CD4⁺T, CD4⁺T/CD8⁺T and natural killer (NK) cells in the HBeAg-positive group were higher than those in the HBeAg-negative group (P<0.05), and the CD8⁺T cell level was lower than that in the HBeAg-negative group (P<0.05). The levels of interferon-γ (IFN-γ), tumor necrosis factor (TNF-α), interleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-17 (IL-17), transforming growth factor-β (TGF-β) in the HBeAg-positive group were substantially higher than those of the HBeAg-negative group (P<0.05). The levels of interleukin-4 (IL-4) and interleukin-10 (IL-10) in the HBeAg-positive group were not significantly different from those in the HBeAg-negative group (P>0.05). Conclusion HBeAg level affects the immune function of patients with HBV/TP coinfection, which may induce the body to start cellular immunity, improve the level of T lymphocyte subsets and promote the secretion of related cytokines.

Key words: Hepatitis B virus e antigen, Hepatitis B virus, Treponema pallidum, Overlapping infection, Cellular immune function

陈思宇, 白兰, 张锦. HBeAg状态对HBV/TP重叠感染患者细胞免疫功能的分析[J]. 新发传染病电子杂志, 2021, 6(4): 298-301.

Chen Siyu, Bai Lan, Zhang Jin. Analysis of cellular immune function in patients with HBV/TP superinfection with different HBeAg status[J]. Electronic Journal of Emerging Infectious Diseases, 2021, 6(4): 298-301.

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