隐球菌荚膜抗原检测在隐球菌病中的诊断价值

doi:10.19871/j.cnki.xfcrbzz.2021.01.013

新发传染病电子杂志 ›› 2021, Vol. 6 ›› Issue (1): 58-61.doi: 10.19871/j.cnki.xfcrbzz.2021.01.013

隐球菌荚膜抗原检测在隐球菌病中的诊断价值

陈力¹, 何小庆², 陈耀凯²

1.重庆市公共卫生医疗救治中心急诊科,重庆 400036;
2.重庆市公共卫生医疗救治中心感染科,重庆 400036

收稿日期:2020-08-25 出版日期:2021-02-28 发布日期:2021-03-03
通讯作者: 陈耀凯,E-mail: yaokaichen@hotmail.com
基金资助:
“十三五”国家科技重大专项（2018ZX10302104）; 重庆市医学科研重点项目（2019ZDXM012）

The value of detecting cryptococcal antigen in the diagnosis of cryptococcosis

Chen Li¹, He Xiaoqing², Chen Yaokai²

1. Department of Emergency, Chongqing Public Health Medical Center, Chongqing 400036, China;
2. Department of Infectious Diseases, Chongqing Public Health Medical Center, Chongqing 400036, China

Received:2020-08-25 Online:2021-02-28 Published:2021-03-03

摘要/Abstract

摘要： 隐球菌病是由隐球菌感染人体引起的一种侵袭性真菌病,是艾滋病患者及实体器官移植者中常见的感染和致死原因。10年来,隐球菌病的诊断方法已从真菌培养、墨汁染色,到目前的隐球菌荚膜抗原（cryptococcal capsular antigen,CrAg）检测。CrAg检测操作简便快速,花费少,敏感性及特异性高,因此在世界范围内得到广泛应用。世界卫生组织推荐对高危人群进行CrAg筛查,对CrAg阳性患者进行抢先治疗,从而降低病死率。本文就CrAg检测在隐球菌病中的诊断价值展开综述。

关键词: 隐球菌荚膜抗原, 隐球菌病, 诊断价值

Abstract: Cryptococcosis is an invasive fungal disease caused by cryptococcosis,it is a common cause of infection and death among AIDS patients and solid organ transplant recipients.In the past ten years, the diagnostic methods for cryptococcosis have ranged from fungal culture and ink staining to the current detection of cryptococcal capsular antigen (CrAg).CrAg detection is simple and fast, inexpensive, high sensitivity and specificity, so it is widely used worldwide.The World Health Organization recommends CrAg screening for high-risk groups and preemptive treatment of CrAg-positive patients to reduce the mortality rate.This article reviews the value of cryptococcal capsularantigendetecting in the diagnosis of cryptococcosis.

Key words: Cryptococcal capsular antigen, Cryptococcosis, Diagnosis

陈力, 何小庆, 陈耀凯. 隐球菌荚膜抗原检测在隐球菌病中的诊断价值[J]. 新发传染病电子杂志, 2021, 6(1): 58-61.

Chen Li, He Xiaoqing, Chen Yaokai. The value of detecting cryptococcal antigen in the diagnosis of cryptococcosis[J]. Electronic Journal of Emerging Infectious Diseases, 2021, 6(1): 58-61.

参考文献

[1] 关家龙, 李粤平, 蔡卫平. 艾滋病合并新型隐球菌性脑膜炎100例临床分析[J]. 国际医药卫生导报, 2014, 20(9):1185-1187.
[2] AIVIS JN, PERCIVAL A, BAUMAN S, et al.Evaluation of a novel point-of-care cryptococcal antigen test on serum, plasma, and urine from patients with HIV-associated cryptococcal meningitis[J]. Clin Infect Dis, 2011, 53(10):1019-1023.
[3] 中华医学会感染病学分会. 隐球菌性脑膜炎诊治专家共识[J]. 中华传染病杂志, 2018, 36(4):193-199.
[4] 王露霞, 刘海英, 石凌波, 等. 隐球菌荚膜多糖抗原乳胶凝集试验干扰因素的探讨[J]. 临床检验杂志, 2010, 28(2):159.
[5] "十三五"国家科技重大专项艾滋病机会性感染课题组. 艾滋病合并隐球菌病临床诊疗的专家共识[J]. 西南大学学报(自然科学版), 2020, 42(7):1-19.
[6] BOULWARE DR, MEYA DB, BERGEMANN TL, et al.Clinical features and serum biomarkers in HIV immune reconstitution inflammatory syndrome after cryptococcal meningitis: a prospective cohort study[J]. PLOS Med, 2010, 7(12):e1000384.
[7] 陶然,师金川,郭永征,等. 两性霉素B去氧胆酸盐、两性霉素B脂质体和伏立康唑诱导治疗HIV相关性隐球菌脑膜炎的效果比较[J/CD]. 新发传染病电子杂志,2019,4(1):97-102.
[8] Guidelines for The Diagnosis, Prevention and Management of Cryptococcal Disease in HIV-Infected Adults, Adolescents and Children: Supplement to the 2016 Consolidated Guidelines on the Use of Antiretroviral Drugs for Treating and Preventing HIV Infection. Geneva: World Health Organization, the 2016 Consolidated Guidelines on the Use of Antiretroviral Drugs for Treating and Preventing HIV Infection. Geneva: World Health Organization, March 2018.
[9] MCMULLAN BJ, HALLIDAY C, SORRELL TC, et al.Clinical utility of thecryptococcal antigen lateral flow assay in a diagnostic mycologylaboratory[J]. PLoS One, 2012, 7(11):e49541.
[10] 季淑娟, 倪玲红, 张俊丽, 等. 不同荚膜抗原检测方法对隐球菌脑膜脑炎诊断和疗效评估的价值[J]. 中华医学杂志, 2015, 95(46):3733-3736.
[11] LONGLEY N, JARVIS JN, MEINTJES G, et al.Cryptococcal antigen screening in patients initiating ART in South Africa: a prospective cohort study[J]. Clin Infect Dis, 2016, 62(5):581-587.
[12] JARVIS JN, HARRISON TS, LAWN SD, et al.Cost effectiveness of cryptococcal antigen screening as a strategy to prevent HIVassociatedcryptococcal meningitis in South Africa[J]. PLoS One, 2013, 8(7):e69288.
[13] RADHA R, RACHEL MW, TAFESE B, et al.Cryptococcal Meningitis Diagnostics and Screening in the Eraof Point-of-Care Laboratory Testing[J]. J Clin Microbiol, 2019, 1(57):e01238-18.
[14] WILLIAMSON PR, JARVIS JN, PANACKAL AA, et al.Cryptococcal meningitis: epidemiology, immunology, diagnosis and therapy[J]. Nat Rev Neurol, 2017,13(1):13-24.
[15] 傅顺金, 许攀峰, 周华, 等. 52例肺隐球菌病的临床及影像特点与隐球菌荚膜抗原检测结果的关系[J]. 中华医院感染学杂志, 2018, 28(22):3397-3400, 3409.
[16] 陈栎江, 吴庆, 徐春泉, 等. 血清隐球菌荚膜多糖抗原检测在肺隐球菌病中的早期诊断价值[J]. 中国抗生素杂志, 2018, 43(10):1248-1251.
[17] 黄佳斯, 石磊, 唐爱国, 等.胶体金免疫层析法检测血清隐球菌抗原在肺隐球菌病诊断中的应用价值[J].临床检验杂志, 2017, 35(7):518-519.
[18] SENGHOR Y, GUITARD J, ANGOULVANT A, et al.Cryptococcal antigen detection inbroncho-alveolar lavage fluid[J]. Med Mycol, 2018, 56(6):774-777.
[19] NOGUCHI H, MATSUMOTO T, KIMURA U, et al.Cutaneous Cryptococcosis[J]. Med Mycol J, 2019, 60(4):101-107.
[20] KOTHIWALA SK, PRAJAPAT M, KULDEEP CM, et al.Cryptococcal panniculitis in a renal transplant recipient: case report and review of literature[J]. J Dermatol Case Rep, 2015, 9(3):76-80.
[21] KIKUCHI N, HIRAIWA T, ISHIKAWA M, et al.Cutaneous cryptococcosis mimicking pyoderma gangrenosum: A report of four cases[J]. Acta Derm Venereol, 2016, 96(1):116-117.
[22] 《中国真菌学杂志》编辑委员会.隐球菌感染诊治专家共识[J].中国真菌学杂志, 2010, 5(2):65-68,86.
[23] 廖万清, 陈敏, 方文捷. 医学真菌研究的前沿及热点[J/CD]. 新发传染病电子杂志, 2018, 3(3):129-133.

隐球菌荚膜抗原检测在隐球菌病中的诊断价值

The value of detecting cryptococcal antigen in the diagnosis of cryptococcosis

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 1

编辑推荐

Metrics

本文评价