Abstract: Objective Discuss with FloTrac - Vigileo system monitoring hemodynamic goal-directed fluid therapy in patients with tuberculous damaged lung pneumonectomy and the effect of postoperative complications. Method From January 2020 to December 2021, patients with tuberculous destroyed lung (TDL) who did not respond to medical treatment and had received total pneumonectomy in our hospital were randomly stratified. Group S was randomly selected from 19 surgical patients who were treated with FloTrac - Vigileo and group C was randomly selected from 20 patients who were not treated with FloTrac - Vigileo. A total of 39 patients were selected. Hemodynamic parameters of 2 groups were recorded when patients entered the operating room (T0), after endotracheal intubation (T1), at the beginning of surgery (T2), after pulmonary artery occlusion (T3) and at the end of surgery (T4). The amount of fluid used during operation, operation time, operation blood loss, use of vasoactive drugs and use of diuretics after operation were analyzed. Postoperative complications were observed. Result There were no statistically significant differences in the general situation, operation time and amount of surgical bleeding between the two groups (P>0.05); There were no significant differences in intraoperative mean arterial pressure (MAP) and heart rate (HR) between 2 groups (P>0.05). In terms of liquid use between the two groups, the total amount of infusion in group S was significantly lower than that in group C, with an increase in colloidal amount and a decrease in crystal amount (P<0.05), while there was no significant difference in the amount of transfusion (P>0.05). 3. The number of intraoperative vasoactive drugs used in group S was lower than that in group C, and the number of post-operative diuretics used in group S was lower than that in group C, with statistical differences (P<0.05). 4. Postoperative complications were observed, postoperative complications were reduced in group S, especially pulmonary edema, and the incidence of hypotension was significantly reduced, with statistical differences (P<0.05). Conclusion Using FloTrac - Vigileo to monitor hemodynamics and conduct target-directed fluid therapy can guide more reasonable and effective intraoperative fluid therapy and precise drug use in total lung resection for TDL patients, which has important reference significance for reducing the incidence of serious postoperative complications and speeding up postoperative recovery.

Key words: FloTrac-Vigileo system, Tuberculous destroyed lung, Lesions pneumonectomy, Fluid therapy