People's Health Press
ISSN 2096-2738 CN 11-9370/R
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Electronic Journal of Emerging Infectious Diseases ›› 2020, Vol. 5 ›› Issue (4): 268-273.doi: 10.19871/j.cnki.xfcrbzz.2020.04.012

• Review • Previous Articles     Next Articles

Progress on coronavirus disease2019vaccines: current status

Li Qian, Lu Hongzhou   

  1. Department of Infectious Diseases,Shanghai Public Health Clinical Center,Shanghai 201508,China
  • Received:2020-11-17 Online:2020-11-30 Published:2020-12-31

Abstract: The ongoing pandemic of coronavirus disease-2019 (COVID-19) has led to severe global health burden.However,no effective vaccine has been developed yet.The development of a safe and effective COVID-19 vaccine is urgent for the disease control.In the present review,we firstly described the mechanisms of neutralizing antibodies-mediated immune responses.We elucidated different neutralizing antibodies which are induced by Coronavirus vaccines,and described how they induce anti-viral response.Secondly,we took the severe acute respiratory syndrome coronavirus (SARS-CoV) and the Middle East respiratory syndrome coronavirus (MERS-CoV) as examples,and summarized how the new coronavirus (SARS-CoV2) vaccine development can learn from SARS and MERS vaccine research in selecting antigens.Furthermore,we discussed the potential problems for COVID-19 vaccine development about evaluating the safety and effectiveness of SARS-CoV and MERS-CoV vaccines.Next,we summarized the current clinical trials of COVID-19 vaccines.Although there are challenges from the clinical trials to large-scale production and application,the development of vaccines is so rapidly nowadays,and it’s potential to get safe and effective vaccines in a short time.At last,the vaccines strategy should be combined with public health strategies such as keeping physical distance,early detection,self-isolation and outbreak control to against COVID-19.

Key words: Coronavirus, Coronavirus disease-2019, Neutralizing antibodies, Vaccines, Safety